Labs

The Altman lab focuses on use of whole genome transcriptional profiling and multi-omics approaches, and leverages big-data computational biology to understand the molecular mechanisms underpinning severe asthma and other immunologic diseases.

The main focus of the Bettelli Lab is to identify the cell types of the immune system and mechanisms, which induce and regulate the development of autoimmunity.

The Buckner Lab is focused on identifying the underlying mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. 

The Byrd Lab investigates the role of microorganisms in health and disease, with a particular focus on the gut microbiome — a complex community of bacteria, fungi and viruses that influence immune system activity, disease progression, and response to therapy.

The Campbell laboratory is interested in understanding the basis for T cell activation, function and tolerance.

Dr. Cerosaletti’s research is focused on the role of the adaptive immune system in the development and progression of immune mediated diseases and the response to treatment.

Our group focuses on prediction and prevention of type 1 diabetes (T1D) as well as discovery and validation of biomarkers of disease progression and response to therapy.

The lab is interested in understanding how myeloid cells contribute to both productive and pathological immune responses during infection, inflammation, and autoimmune diseases.

The Harrison Lab studies the mechanisms controlling host-microbe interactions at barrier tissues, primarily the skin and the gut with the goal to understand how these immune cells promote barrier tissue integrity and repair, and to understand how this goes awry during disease.

The James lab is working to develop an increasingly in depth knowledge of autoreactive T cell responses by examining the characteristics of the epitope specific cells involved in autoimmune diseases through robust multi-parameter assays and also at the single cell level.

The Khor Lab is pioneering new ways to understand how the immune system works and why it sometimes goes awry.

The Kwok lab uses tetramers and other antigen specific T cell assays to examine autoreactive T cells in  autoimmune diseases in order to provide insights into disease mechanisms and identify strategies for disease intervention.

Researchers in the Lacy-Hulbert Lab study how components of the immune system work together to defend against harmful invaders while avoiding damage to healthy tissues or harmless microbes.

Our goal is to develop and use cutting edge systems biology approaches to elucidate molecular signatures of complex immune diseases, understand the mechanisms of disease, and identify the right therapy for the right patient.

The Long Lab focuses on understanding mechanisms of tolerance, why they are lost in autoimmunity, and how tolerance can be augmented with therapy.

The Lord lab is investigating how loss of “tolerance” happens in IBD, to learn how the immune system normally coexists peacefully in close proximity to gut contents.

The Mikacenic lab is focused on understanding how lung immune cells contribute to inflammation, repair, and fibrosis.

The Morawski lab studies the adaptive immune response occurring during human inflammatory and autoimmune diseases of the skin and other barrier tissues.

The Ray Lab is interested in better understanding how genetic variation tunes our immune system and how this can put individuals at risk for autoimmune diseases.

The Speake group is interested in advancing clinical research – especially in type 1 diabetes, but also in the context of other immune-mediated diseases.

The goal of our research is to better understand mechanisms of sensing and repair during diseases like cancer, infections, and neurodegenerative disorders.

The Ziegler laboratory is investigating the role of the epithelial cytokines TSLP and IL-33 in regulating protective responses at mucosal barrier surfaces such as the respiratory and gastrointestinal tracts.