Cerosaletti Lab

Introduction

Dr. Cerosaletti’s research is focused on the role of the adaptive immune system in the development and progression of immune mediated diseases and the response to treatment.

Current research is examining the role of T cells in the development and progression of autoimmune type 1 diabetes (T1D), and the response to immunotherapy in T1D. The lab is identifying transcriptional and T cell receptor signatures of islet autoreactive CD4 T effector cells and regulatory T cells that are linked to disease course.

The Cerosaletti lab is also examining the expansion of stem-like CD4 memory T cells in T1D which may serve as a reservoir of autoreactive T cells in T1D.

Additionally, Dr. Cerosaletti has a longstanding research interest in the molecular genetics of immune disorders to establish functional links between genetic variants and alterations in the immune response leading to loss of tolerance, viral response and response to therapy. Current work is focused on the impact of genetic variants in the response to peanut allergy immunotherapy. 

Karen Cerosaletti
Director, Center for Translational Immunology

Karen Cerosaletti, PhD

Director, Center for Translational Immunology; Associate Member; Principal Investigator, Cerosaletti Lab
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Lab Members

Janice Chen

Janice Chen

Research Technician, Cerosaletti Lab; Center for Translational Immunology
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Meenakshi Dunga

Meenakshi Dunga

Research Technician, Cerosaletti Lab; Center for Translational Immunology
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Ami Wei

Shan (Ami) Wei

Research Technician, Cerosaletti Lab; Center for Translational Immunology
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Research Projects

Cerosaletti Research Project Preview - Autoreactive T cells in type 1 diabetes

Autoreactive T cells in type 1 diabetes

The lab is investigating autoreactive effector and regulatory T cells in T1D using single cell RNA sequencing to identify features of these cells that are linked to disease course or response to therapy.
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Cerosaletti Research Project Preview - Genetics of response to allergy immunotherapy

Genetics of response to allergy immunotherapy

The Cerosaletti Lab is studying the role of genetic variation in the HLA class II genes in the response to peanut oral immunotherapy by analysis of antigen presentation and recognition by peanut specific T cells.
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Cerosaletti Research Project Preview - Stem-like memory CD4 T cells in type 1 diabetes

Stem-like memory CD4 T cells in type 1 diabetes

The Cerosaletti lab is studying stem-like memory CD4 T cells (Tscm) in T1D to understand the mechanism leading to expansion of these cells  in T1D and determine if Tscm levels influence disease progression and response to therapy.
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Related Stories

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March 17, 2022

Exploring Alpha: Deep Dive into T Cells Unveils Possible Driver of T1D

A team led by Peter Linsley, PhD, and Karen Cerosaletti, PhD, recently uncovered a clue that could help solve the mystery of why and how T1D starts and maybe even open the door to new therapies that stop the disease.

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June 15, 2021

Understanding EOE: New Studies Shed Light on Complex Condition

Eosinophilic esophagitis (EOE), a rare immune system condition that’s connected to food allergies and causes serious inflammation in the esophagus. A BRI research team, led by Karen Cerosaletti, PhD, and Steven Ziegler, PhD, launched a study asking some key questions about EOE.

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December 21, 2020

Volunteering in a COVID-19 Vaccine Trial: BRI Team Members Share Their Experience

Without clinical research participants, we might not have groundbreaking cancer treatments like immunotherapy or vaccines for polio, rubella and other life-threatening diseases.

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News

News Science in Seattle

Science in Seattle: A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab

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News Science in Seattle

Publication of the Week: Endomembrane Targeting of Human OAS1 p46 Augments Antiviral Activity

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News Lupus News Today

13 Lupus Research Program Winners Share $5M for Work Advancing Disease Understanding and Treatment

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