Translating Discoveries into Action

From bench to bedside and back again

Scientists in the Center for Translational Immunology study blood and tissue samples from people with immune system diseases including autoimmune diseases, allergies, infectious diseases and cancer. This includes samples from people with Down syndrome, who are at a significantly higher risk of developing an autoimmune disease than the general population. We use advanced systems immunology tools to examine genes, cells and molecules involved in these diseases. Our studies aim to discover how diseases start and progress; identify biological characteristics tied to certain diseases or response to therapy; and to find new drug targets.

We often build on discoveries made by scientists in the Center for Fundamental Immunology, looking for patterns and further testing their theories in human samples. We also work with the Center for Interventional Immunology and pharmaceutical companies to  examine samples from clinical trials to better understand how and why new medicines did or did not impact disease, and to collect data that leads to new therapies.  

Karen Cerosaletti
Director, Center for Translational Immunology

Karen Cerosaletti, PhD

Director, Center for Translational Immunology; Associate Member; Principal Investigator, Cerosaletti Lab
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Labs in the Center for Translational Immunology

Buckner Lab Main

Buckner Lab

The Buckner Lab is focused on identifying the underlying mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. 
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Cerosaletti Research Project Main - Autoreactive T cells in type 1 diabetes

Cerosaletti Lab

Dr. Cerosaletti’s research is focused on the role of the adaptive immune system in the development and progression of immune mediated diseases and the response to treatment.
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James Lab Main

James Lab

The James lab is working to develop an increasingly in depth knowledge of autoreactive T cell responses by examining the characteristics of the epitope specific cells involved in autoimmune diseases through robust multi-parameter assays and also at the single cell level.
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Khor Lab Main

Khor Lab

The Khor lab is interested in understanding novel pathways that regulate tolerance and inflammation, with the goal of developing novel precision therapies. A major focus of the lab is understanding the mechanistic basis of immune dysregulation in people with Down syndrome.
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Kwok Research Project Main - DNA-barcoded HLA class II tetramers

Kwok Lab

The Kwok lab uses tetramers and other antigen specific T cell assays to examine autoreactive T cells in  autoimmune diseases in order to provide insights into disease mechanisms and identify strategies for disease intervention.
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Long Lab Main

Long Lab

The Long Lab focuses on understanding mechanisms of tolerance, why they are lost in autoimmunity, and how tolerance can be augmented with therapy.
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Lord Lab Main

Lord Lab

The Lord lab is investigating how loss of “tolerance” happens in IBD, to learn how the immune system normally coexists peacefully in close proximity to gut contents.
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Mikacenic Lab Main

Mikacenic Lab

The Mikacenic lab is focused on understanding how lung immune cells contribute to inflammation, repair, and fibrosis.
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Feature - Gut Immunity Group

Gut Immunity Program

The Gut Immunity Program studies how immune responses in the gut go wrong and lead to inflammatory bowel diseases (IBD) such as, celiac disease, Crohn's & colitis and other autoimmune conditions. Researchers use model systems, biorepository samples and clinical studies to understand how immune responses go awry. They also study the gut microbiome and how immune responses in the gut contribute to other autoimmune diseases.
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News

News Science in Seattle

Science in Seattle: A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab

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News Immunology Podcast

BRI Investigator Alice Long, PhD, Interviewed on the Immunology Podcast

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Blog Main Image - Down Syndrome (DS) Girl Under Mother Arm

Benaroya Research Institute Receives $9 Million in Funding, With a Focus on Down Syndrome Research

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