The Buckner Lab is focused on identifying the underlying mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Our multipronged approach integrates the study of genes associated with disease risk, the study of lymphocyte populations implicated in the pathogenesis of autoimmune disease and the analysis of carefully curated biological samples from well-characterized subjects with type 1 diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus and relapsing polychondritis.
The goal in all of our studies is to understand how pathways known to regulate the immune response are altered in the setting of disease, and further when and how these mechanisms of failed tolerance contribute to the development and progression of human disease.
Jane Buckner, MD
Arpit Mishra, PhD
Jing Song, PhD
Ritika Tewari, PhD
Soo Jung Yang, PhD
Altered T cell function in human autoimmune disease
The Buckner lab has a long-standing interest in understanding how T cell function is altered in human autoimmune disease.