Introduction
The Buckner Lab is focused on identifying the underlying mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Our multipronged approach integrates the study of genes associated with disease risk, the study of lymphocyte populations implicated in the pathogenesis of autoimmune disease and the analysis of carefully curated biological samples from well-characterized subjects with type 1 diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus and relapsing polychondritis.
The goal in all of our studies is to understand how pathways known to regulate the immune response are altered in the setting of disease, and further when and how these mechanisms of failed tolerance contribute to the development and progression of human disease.
Jane Buckner, MD
Lab Members
Aleah DeSchmidt
Ethan McClain
Arpit Mishra, PhD
Emma Mortensen
Sylvia Posso
Cliff Rims
Jing Song, PhD
Megan Tatum
Ritika Tewari, PhD
Soo Jung Yang, PhD
Nadir Ziane
Research Projects
Altered T cell function in human autoimmune disease
The Buckner lab has a long-standing interest in understanding how T cell function is altered in human autoimmune disease.
Regulatory T cells in the context of autoimmune disease
Antigen-specific T cells in autoimmunity
Featured Publications
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Oct 2022
IL-6-targeted therapies directed to cytokine or receptor blockade drive distinct alterations in T cell function.
Speake C, Habib T, Lambert K, Hundhausen C, Lord S, Dufort MJ, Skinner SO, Hu A, Kinsman M, Jones BE, Maerz MD, Tatum M, Hocking AM, Nepom GT, Greenbaum CJ, Buckner JH -
Oct 2022
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.
Yang SJ, Singh AK, Drow T, Tappen T, Honaker Y, Barahmand-Pour-Whitman F, Linsley PS, Cerosaletti K, Mauk K, Xiang Y, Smith J, Mortensen E, Cook PJ, Sommer K, Khan I, Liggitt D, Rawlings DJ, Buckner JH -
Jul 2022
IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation.
Lambert K, Diggins KE, Jones BE, Hundhausen C, Maerz MD, Hocking AM, Sanda S, Greenbaum CJ, Linsley PS, Cerosaletti K, Buckner JH -
Feb 2022
Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes.
Jones BE, Maerz MD, Bahnson HT, Somasundaram A, McCarthy LH, Speake C, Buckner JH -
Mar 2021
Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis.
Song J, Schwenzer A, Wong A, Turcinov S, Rims C, Martinez LR, Arribas-Layton D, Gerstner C, Muir VS, Midwood KS, Malmström V, James EA, Buckner JH
Learning How Tregs Keep Your Immune System in Check
BRI's Vision of Immune Health
A Heartfelt Thank You: One Scientist Shares How Donors Make an Impact at BRI
This giving season, on behalf of our team, I extend a heartfelt thank you to all BRI donors and share some of the meaningful ways your philanthropy supports our work.
BRI Investigators Jane Buckner, MD, and Carmen Mikacenic, MD, Interviewed on the Arthritis Life Podcast
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Science in Seattle: New Study from BRI and the UW Identify Novel Mechanism of Regulatory T Cells’ Role in Maintaining Immune System Homeostasis
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