Faculty & Scientific Staff
Jane Buckner, MD
Background Information
Jane Buckner is the President of the Benaroya Research Institute, an affiliate Professor at the University of Washington and practicing rheumatologist. She is known for her research in translational immunology, combining genetics, immunology and clinical medicine to advance the understanding of the causes of autoimmune diseases. At the Benaroya Research Institute, Dr. Buckner was instrumental in developing the translational immunology research program and establishing the BRI biorepository, which currently includes more than 350,000 samples from 14,000 participants. Dr. Buckner has made significant contributions to our understanding of how human T cells are dysregulated in type 1 diabetes and rheumatoid arthritis and has been a pioneer in the development of antigen-specific Treg therapies. Dr. Buckner is the inaugural holder of the Gerald Nepom Endowed Chair at BRI. She also leads the Coordinating Center of the Immune Tolerance Network, an NIH funded collaborative network for clinical research and is a scientific advisor for Type 1 Diabetes TrialNet, an NIH-funded clinical trial network for type 1 diabetes prevention and early treatment. She recently served as the chair of the NIH/NIAMS Board of Scientific Counselors and in 2024 was awarded the American Association of Immunologists Steinman Award for Human Immunology Research.
Featured Publications
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Specificity, frequency, and phenotype of citrullinated-specific T cells vary with disease activity in rheumatoid arthritis
JCI InsightCliff Rims, Hannah A DeBerg, Sylvia E Posso, Virginia S Muir, Hannes Uchtenhagen, Anne M Hocking, Heather Bukiri, Jeffrey Carlin, Bernard Ng, Peter S Linsley, Eddie A James, Jane H Buckner -
Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes.
Science Translational MedicineSmithmyer ME, Hu A, Dufort MJ, Hocking AM, Wiedeman AE, Fasano KJ, Torgerson TR, Skene PJ, Reading J, Li X, Gong Q, Long SA, Lacy-Hulbert A, Gustafson CE, Buckner JH, Speake C, members of the BRI Sound Life Project Team, BRI Sound Life Project Team -
Antigen-specific immunotherapies for autoimmune disease.
Nature Reviews. RheumatologyBuckner JH -
Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy.
Journal of AutoimmunityTewari R, Yang SJ, McClain ED, Hu A, Mortensen E, DeSchmidt A, Chen J, Kancharla A, Singh AK, James EA, Burman BE, Siddique A, Rawlings DJ, Patel C, Cerosaletti K, Buckner JH -
Translational Immunology: Applying fundamental discoveries to human health and autoimmune diseases.
European Journal of ImmunologyBuckner JH