Human Immunophenotyping Core

HIP Core

The Human Immunophenotyping (HIP) core at the Benaroya Research Institute (BRI) provides access to cutting-edge technologies and services enabling study of human immune-mediated diseases.

We offer expertise in human immunology along with innovative assays and state-of-the-art technology. We specialize in robust, high-parameter single-cell assays utilizing conventional, spectral, and mass cytometry (CyTOF), which can be paired with sophisticated genomic and bioninformatic analyses through our connections with other outstanding BRI cores. Other services include, but are not limited to, cell sorting, short-term in vitro assays, DNA/RNA extraction, qPCR, and ELISA or multiplex protein analysis (Luminex).

We tailor our support to meet the unique needs of each researcher. A full spectrum of services is available, from guidance on study design and training on new technologies through to execution, data analysis and interpretation. The HIP core serves investigators from BRI and Virginia Mason Medical Center (VMMC) as well as other institutions, including both non- and for-profit organizations.

HIP Core Manager

Alice Wiedeman, PhD

Manager, Human Immunophenotyping Core Lab; Center for Translational Immunology

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Dr. Alice Wiedeman has studied the human immune system for nearly two decades;

she is passionate about advancing human health through team science and cutting-edge technologies.

In the HIP core, Alice collaborates with other scientists across a range of fields, to develop innovative assays tailored to the researchers needs, and deliver high-quality results. She keeps apprised the best practices and latest technologies, including high-parameter cytometry data analysis tools.

Alice is an active member in the cytometry and immunology communities—she volunteers with the International Society for Advancement of Cytometry (ISAC) and the Northwest Flow Cytometry Society (NWFCS), she founded the Seattle CyTOF Users Group monthly meeting series, and she is an active member of ISAC, the American Association of Immunologists (AAI), and the Federation of Clinical Immunology Societies (FOCiS).