Explore the genome

Genomics Core

The Genomics Core provides resources to BRI and external investigators for genomics analysis, from sample processing through data generation, as well as basic bioinformatics analysis, provided by our Bioinformatics Group.

Currently available technologies focus on Illumina RNA and DNA sequencing from purified nucleic acid, sorted cell populations, or single cells. RNA-seq is used primarily for whole transcriptome profiling and can be performed from a variety of sample types, including purified total RNA, cell populations (including low input samples of 50-1000 cells), or single cells (both plate-sorted rare populations and high-throughput single-cell analyses). DNA-seq pipelines can also be performed, including bulk and single cell CUT&Tag/CUT&RUN, ATAC-seq, whole exome, and whole genome.

Vivian Gersuk
Genomics Core Lab Manager

Vivian Gersuk, PhD

Manager, Genomics Core Lab
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The Core laboratory houses two Illumina sequencers, a NextSeq2000 and a Miseq. The NextSeq2000 uses patterned flowcell technology and offers three flowcell sizes —100M reads, 500M reads and 1300M reads — each available in several run lengths. The MiSeq has a variety of flowcells sizes, from 1M to 25M reads.

Additionally, the Core offers single cell sequencing, using either a 10x Genomics Chromium X or a Chromium Controller, for high throughput single cell capture and processing. Other available equipment includes an Agilent TapeStation 4200 (to measure RNA/DNA integrity and size) and a Tecan NanoQuant (for high throughput sample quantitation). Ancillary equipment for sample processing includes a Formulatrix Mantis Liquid Handler, a Qiagen QIAgility (also a liquid handling robot), a ThermoFisher Kingfisher Flex, which extracts nucleic acid from a variety of samples, using magnetic bead technology, with a throughput of up to 96 samples and two Qiagen QIAcube Connect instruments, which automate extraction of nucleic acid using spin column technology.

Genomics Core Staff

Quynh Anh Nguyen

Quynh-Anh Nguyen

Research Technician, Genomics Core Lab
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Kimberly O'Brien

Kimberly O'Brien

Supervisor, Genomics Core Lab
Greg Thiessen

Greg Thiessen

Research Technician, Genomics Core Lab
Jeffrey Yaplee

Jeffry Yaplee

Research Technician, Genomics Core Lab
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Core Genomics Tech - NextSeq 2000

Illumina NextSeq 2000

Next Generation Sequencing
Core Genomics Tech - Illumina MiSeq

Illumina MiSeq

Next Generation Sequencing
Genomics Core Tech - Chromium X

10x Chromium X

Genomics Core Tech - Agilent Tapestation 4200

Agilent Tapestation 4200

Genomics Core Tech - Formulatrix Mantis

Formulatrix Mantis

Core Genomics Tech - Kingfisher Flex

ThermoFisher KingFisher Flex

Nucleic Acid Purification
Core Genomics Tech - QiaCube

Qiagen QIAcube Connect

Nucleic Acid Purification