Campbell Lab


The Campbell laboratory is interested in understanding the basis for T cell activation, function and tolerance. We use both animal models and human samples to identify functionally relevant populations of effector and regulatory T cells, define the factors that promote their development and maintenance and delineate their roles in healthy immune responses and in immune-mediated diseases.  

We are also work to develop and characterize new methods to promote regulatory T cell activity to treat autoimmune disease.

The lab is also studying how T cells interact with and reprogram the responses of structural cells in the skin to regulate normal tissue function, and understanding how this changes during cutaneous inflammatory diseases. We use an array of innovative techniques in this work, including transcriptional and epigenetic profiling of cells isolated from primary human skin samples, tissue explant cultures and organotypic skin culture models.

Daniel Campbell

Daniel J. Campbell, PhD

Director, Center for Fundamental Immunology; Member; Principal Investigator, Campbell Lab
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Campbell Lab Members

Joseph Albe

Joseph Albe

Graduate Student, Campbell Lab; Center for Fundamental Immunology
Jared Balolong

Jared Balolong

Rotation Student, Campbell Lab; Center for Fundamental Immunology
Manreet Bhullet

Manreet Bhuller

Lab Aide, Campbell Lab; Center for Fundamental Immunology
Mitch Fahning

Mitch Fahning

Research Technician, Campbell Lab; Center for Fundamental Immunology
Braxton Jamison

Braxton Jamison, PhD

Post Doctoral Research Associate, Campbell Lab; Center for Fundamental Immunology
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Sam Klebanoff

Samuel Klebanoff

Graduate Student, Campbell Lab; Center for Fundamental Immunology
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Ayako Takamori, PhD

Staff Scientist, Campbell Lab; Center for Fundamental Immunology

Research Projects

Campbell Lab Res Proj Prev - IL-2 Mutein Therapy

Restoring immune tolerance via regulatory T cell-targeted IL-2 mutein therapy

Boosting regulatory T cell activity with targeted versions of IL-2 to arrest ongoing autoimmunity and restore immune tolerance.
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Campbell Lab Res Proj Prev - T Cell Structural

T cell-structural cell interaction in the skin

The structural cells of the skin have an important role in cutaneous immunity. This project examines how they are reprogrammed by skin-resident T cells, and how this in turn regulates inflammatory and autoimmune diseases at this site.
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