Campbell Lab

Introduction

The Campbell laboratory is interested in understanding the basis for T cell activation, function and tolerance. We use both animal models and human samples to identify functionally relevant populations of effector and regulatory T cells, define the factors that promote their development and maintenance and delineate their roles in healthy immune responses and in immune-mediated diseases.  

We are also work to develop and characterize new methods to promote regulatory T cell activity to treat autoimmune disease.

The lab is also studying how T cells interact with and reprogram the responses of structural cells in the skin to regulate normal tissue function, and understanding how this changes during cutaneous inflammatory diseases. We use an array of innovative techniques in this work, including transcriptional and epigenetic profiling of cells isolated from primary human skin samples, tissue explant cultures and organotypic skin culture models.

Daniel Campbell
Member

Daniel J. Campbell, PhD

Director, Center for Fundamental Immunology; Member; Principal Investigator, Campbell Lab
View Full Bio

Campbell Lab Members

Joseph Albe

Joseph Albe

Graduate Student, Campbell Lab; Center for Fundamental Immunology
Jared Balolong

Jared Balolong

Rotation Student, Campbell Lab; Center for Fundamental Immunology
Manreet Bhullet

Manreet Bhuller

Lab Aide, Campbell Lab; Center for Fundamental Immunology
Mitch Fahning

Mitch Fahning

Research Technician, Campbell Lab; Center for Fundamental Immunology
Braxton Jamison

Braxton Jamison, PhD

Post Doctoral Research Associate, Campbell Lab; Center for Fundamental Immunology
View Bio
Sam Klebanoff

Samuel Klebanoff

Graduate Student, Campbell Lab; Center for Fundamental Immunology
View Bio
Generic Bio Profile

Ayako Takamori, PhD

Staff Scientist, Campbell Lab; Center for Fundamental Immunology

Research Projects

Campbell Lab Res Proj Prev - IL-2 Mutein Therapy

Restoring immune tolerance via regulatory T cell-targeted IL-2 mutein therapy

Boosting regulatory T cell activity with targeted versions of IL-2 to arrest ongoing autoimmunity and restore immune tolerance.
View Project
Campbell Lab Res Proj Prev - T Cell Structural

T cell-structural cell interaction in the skin

The structural cells of the skin have an important role in cutaneous immunity. This project examines how they are reprogrammed by skin-resident T cells, and how this in turn regulates inflammatory and autoimmune diseases at this site.
View Project

Related Stories

Blog Main BRI Summer Interns 2023 Group
September 28, 2023

Meet BRI's Summer 2023 Interns

Each summer, BRI hosts undergraduate interns from universities across the country. They join various BRI labs and departments to take on research projects with mentorship from our scientists. Meet this year's interns and learn about the exciting projects they worked on.
Read Article
Blog Main Scientific Organoid Blue Green
September 21, 2023

Revolutionary Microscope to Fuel Immunology Breakthroughs

What if we could take a blood sample from a person with rheumatoid arthritis, zero in on the immune cells that cause the disease, and watch what they’re doing in real-time video?
Read Article
Blog Main Image - Skin Closeup
September 14, 2022

Exploring New Frontiers of Skin Immunology

Immune cells perform different functions in different parts of the body. Some fight off infections in the skin. Others protect the lungs from pollutants. But how do these cells learn to do the right job in the right place? And why does that process sometimes go wrong?

Read Article

News

Blog Main Image - Down Syndrome (DS) Girl Under Mother Arm

Benaroya Research Institute Receives $9 Million in Funding, With a Focus on Down Syndrome Research

Read More
News Science in Seattle

Human CD4+CD103+ Cutaneous Resident Memory T Cells are Found in the Circulation of Healthy Individuals

Read news ➡
News Journal Science Immunol

Skin Immune Cell Discovery Challenges Beliefs About T Cells and How They Protect Against Infection

Read More