The Campbell laboratory is interested in understanding the basis for T cell activation, function and tolerance. We use both animal models and human samples to identify functionally relevant populations of effector and regulatory T cells, define the factors that promote their development and maintenance and delineate their roles in healthy immune responses and in immune-mediated diseases.
We are also work to develop and characterize new methods to promote regulatory T cell activity to treat autoimmune disease.
The lab is also studying how T cells interact with and reprogram the responses of structural cells in the skin to regulate normal tissue function, and understanding how this changes during cutaneous inflammatory diseases. We use an array of innovative techniques in this work, including transcriptional and epigenetic profiling of cells isolated from primary human skin samples, tissue explant cultures and organotypic skin culture models.
Daniel J. Campbell, PhD
Campbell Lab Members
Joseph Albe
Ayako Takamori, PhD
Research Projects
Restoring immune tolerance via regulatory T cell-targeted IL-2 mutein therapy
T cell-structural cell interaction in the skin
Featured Publications
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells.
Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity.
Cutting Edge: Effect of Disease-Modifying Therapies on SARS-CoV-2 Vaccine-Induced Immune Responses in Multiple Sclerosis Patients.
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells.
In Vivo Expansion of Antigen-Specific Regulatory T Cells through Staggered Fc.IL-2 Mutein Dosing and Antigen-Specific Immunotherapy.
Meet BRI's Summer 2023 Interns
Revolutionary Microscope to Fuel Immunology Breakthroughs
Exploring New Frontiers of Skin Immunology
Immune cells perform different functions in different parts of the body. Some fight off infections in the skin. Others protect the lungs from pollutants. But how do these cells learn to do the right job in the right place? And why does that process sometimes go wrong?
