Harrison Lab

Introduction

The Harrison Lab studies the mechanisms controlling host-microbe interactions at barrier tissues, primarily the skin and the gut. We perform our research in a multidisciplinary and collaborative manner, combining in vivo cellular and molecular immunology, using genetic mouse models, microbiology, transcriptomic, and epigenetic analyses, to understand how commensal-specific immunity contributes to tissue homeostasis and repair.

A major research interest in the lab is studying the role of commensal-specific T and B cells in the skin and gastrointestinal tract. To do so, we have generated new reagents, commensal-specific T and B cell tetramers, and T cell receptor transgenic mice, to enable us to identify, profile, and manipulate commensal-specific immune responses following commensal colonization, and during experimental infection and injury.

Our goal is to understand how these immune cells promote barrier tissue integrity and repair, and to understand how this goes awry during disease.

Oliver Harrison
Assistant Member

Oliver Harrison, DPhil

Assistant Member; Principal Investigator, Harrison Lab
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Lab Members

Samantha Kimmel

Samantha Kimmel

Research Technician, Harrison Lab; Center for Fundamental Immunology
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Viviana Quijada La Rosa

Viviana Quijada La Rosa

Lab Aide, Harrison Lab; Center for Fundamental Immunology
Jasmine Labuda

Jasmine Labuda, PhD

Post Doctoral Research Associate, Harrison Lab; Center for Fundamental Immunology
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Tayla Olsen

Tayla Olsen

Graduate Student, Harrison Lab; Center for Fundamental Immunology
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Sheenam Verma

Sheenam Verma, PhD

Post Doctoral Research Associate, Harrison Lab; Center for Fundamental Immunology; Washington Research Foundation Post-doctoral Fellow
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Research Projects

Harrison Research Project Preview - Understanding how commensal-specific B cell responses are mounted and regulated

Commensal-specific B cells

Understanding how commensal-specific B cell responses are mounted and regulated
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Harrison Research Project Preview - Understanding mechanisms regulating poised immunity in barrier sites

Commensal-Specific T cells

Understanding how commensal-specific T cells influence tissue homeostasis
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Harrison Research Project Preview - Understanding how commensal-specific T cells influence tissue homeostasis

Poised homeostatic immunity

Understanding mechanisms regulating poised immunity in barrier sites
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News

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