Our group focuses on prediction and prevention of type 1 diabetes (T1D) as well as discovery and validation of biomarkers of disease progression and response to therapy. More than 35 years of this work recently led to the first FDA approved disease modifying therapy to delay the onset of T1D in at risk individuals, setting a precedent for treatment before the clinical appearance of other autoimmune diseases as well.
Our highly collaborative team of clinical and translational investigators, biostatisticians, study coordinators, research nurses and administrative support conducts clinical research and clinical trials. This includes academic multi-center and single site trials as well as investigator initiated and early phase industry sponsored studies. Our clinical research studies include short term interventions with mechanistic outcomes termed EMU or Experimental Medicine Unit studies as well as studies testing novel methods for measures of insulin secretion and immune response. Study participants for clinical research and clinical trials come from the 5 state Pacific Northwest region and are seen for research visits on our Clinical Research Center.
![Carla J Greenbaum](/sites/default/files/styles/staff_hero_staff_feature_1x/public/2023-04/bio-greenbaum-carla.jpg?itok=b1jw8erJ)
Carla Greenbaum, MD
Research Projects
![Greenbaum Research Project Preview - Collaboration with Industry Partners](/sites/default/files/styles/horizontal_landing_card_1x/public/2023-04/greenbaum-res-proj-prev-collab-industry-partners.jpg?itok=At7eNrpE)
Collaborations with Industry Partners to test new T1D therapies
![Greenbaum Research Project Preview - Experimental Medicine Unit](/sites/default/files/styles/horizontal_landing_card_1x/public/2023-04/greenbaum-res-proj-prev-experimental-medical-unit.png?itok=-le-GYVm)
Experimental Medicine Unit studies at BRI
![Greenbaum Research Project Preview - Immune Tolerance Network](/sites/default/files/styles/horizontal_landing_card_1x/public/2023-04/greenbaum-res-proj-prev-itn-clinical-trials.png?itok=Vep05CMJ)
Immune Tolerance Network (ITN) clinical trials in type 1 diabetes
![Greenbaum Research Project Preview - Type 1 Diabetes TrialNet](/sites/default/files/styles/horizontal_landing_card_1x/public/2023-04/greenbaum-res-proj-prev-t1d-trialnet.png?itok=-oGYCZXy)
TrialNet clinical trials in those at risk of type 1 diabetes
Lab Members
![Anna Barash](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-anna-barash.jpg?itok=MvxdevUe)
Anna Barash, MSN, RN, CDCES
![Bio Henry Barnes](/sites/default/files/styles/profile_lab_member_card_1x/public/2024-06/Bio%20Henry%20Barnes.jpg?itok=hmrB1KPu)
Henry Barnes
![Bio Tyler Bartholome](/sites/default/files/styles/profile_lab_member_card_1x/public/2024-03/Bio%20Tyler%20Bartholome.jpg?itok=jfrWnzzj)
Tyler Bartholome
![Emily Batts](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-emily-batts.jpg?itok=o8tuzGpH)
Emily Batts
![Katie Bennett](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-katie-bennett.jpg?itok=V0ls4Vmx)
Katie Bennett
![Kassidy Benoscek](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-kassidy-benoscek.jpg?itok=0ju4Mwpe)
Kassidy Benoscek
![Natalie Clary](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-natalie-clary.jpg?itok=GgyyJgfK)
Natalie Clary
![Bio Arlene Colmenares](/sites/default/files/styles/profile_lab_member_card_1x/public/2024-04/Bio%20Arlene%20Colmenares.jpg?itok=dsO1pQYw)
Arlene Colmenares
![Ren Green](/sites/default/files/styles/profile_lab_member_card_1x/public/2024-07/Bio%20Ren%20Green.jpg?itok=DHBEDcdA)
Ren Green
![Deric Khuat](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-04/bio-deric-khuat.jpg?itok=5ekT86D2)
Deric Khuat
![Rishab Kotak](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-rishab-kotak.jpg?itok=rTIVQYaN)
Rishab Kotak
![David Lee](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-david-lee.jpg?itok=yhGZ7vyI)
David Lee
![Sandra Lord](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-04/bio-lord-sandra.jpg?itok=jQBduPHs)
Sandra Lord, MD
![Ella McGuigan](/sites/default/files/styles/profile_lab_member_card_1x/public/2024-01/Bio%20Ella%20McGuigan.jpg?itok=Vx_CRxNB)
Ella McGuigan
![Courtney Mills](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-courtney-mills.jpg?itok=oLAldMma)
Courtney Mills
![Sunitha Murali](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-sunitha-murali.jpg?itok=EbSt-IoJ)
Sunitha Murali
![Bao Ng](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-bao-ng.jpg?itok=04Vb46bb)
Bao Ng, DNP, ARNP
![Megan Olson](/sites/default/files/styles/profile_lab_member_card_1x/public/2024-02/Bio%20Megan%20Olson.jpg?itok=cnYyT2nr)
Megan Olson
![Katelyn Orcino](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-katelyn-orcino.jpg?itok=go-_SWW7)
Katelyn Orcino
![Arielle Pagryzinski](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-arielle-pagryzinski.jpg?itok=w3o46q3n)
Arielle Pagryzinski, MPH, MS
![Sarah Robinson](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-04/bio-sarah-robinson.jpg?itok=3W058-nQ)
Sarah Robinson
![Cate Speake](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-04/bio-speake-cate.jpg?itok=8FvnxG4x)
Cate Speake, PhD
![Jodie Stroeve](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-04/bio-jodie-stroeve.jpg?itok=dECqQ4K9)
Jodie Stroeve
![William Thornton](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-05/bio-william-thornton.jpg?itok=kk8s3-H2)
William Thornton
![Danielle Tom](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-danielle-tom.jpg?itok=q6On1-FG)
Danielle Tom
![Corinna Tordillos](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-corinna-tordillos.jpg?itok=lzGQghFs)
Corinna Tordillos
![Dana VanBuecken](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-dana-vanbuecken.jpg?itok=onCE987S)
Dana VanBuecken, ARNP
![Kim Varner](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-03/bio-kim-varner.jpg?itok=YWdmWeAO)
Kim Varner
![Marlie Wells](/sites/default/files/styles/profile_lab_member_card_1x/public/2023-04/bio-marlie-wells.jpg?itok=54Ug4nGx)