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Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
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Targeting the Extracellular Matrix Promotes Healing Following Myocardial Infarction.
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Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate.
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Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain.
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Alveolar Macrophage Transcriptional Programs Are Associated with Outcomes in Acute Respiratory Distress Syndrome.
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A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals
MicrobiomeScepanovic P, Hodel F, Mondot S, Partula V, Byrd AL, Hammer C, Alanio C, Bergstedt J, Patin E, Touvier M, Lantz O, Albert ML, Duffy D, Quintana-Murci L, Fellay J, Milieu Intérieur Consortium. -
Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study.
Front ImmunolSpeake C, Bahnson HT, Wesley JD, Perdue N, Friedrich D, Pham MN, Lanxon-Cookson E, Kwok WW, Sehested Hansen B, von Herrath M, Greenbaum CJ -
Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells.
J ImmunolMeckiff BJ, Ladell K, McLaren JE, Ryan GB, Leese AM, James EA, Price DA, Long HM -
Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes.
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A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract.
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Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes.
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An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.
N Engl J MedHerold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ, Type 1 Diabetes TrialNet Study Group. -
Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology.
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Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes.
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Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D.
Curr Opin Endocrinol Diabetes ObesLinsley PS, Long SA
