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Mar 2020
Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates.
DiabetologiaBogdani M, Speake C, Dufort MJ, Johnson PY, Larmore MJ, Day AJ, Wight TN, Lernmark A, Greenbaum CJ -
Mar 2020
Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison.
J Clin Endocrinol MetabSpeake C, Ylescupidez A, Neiman D, Shemer R, Glaser B, Tersey SA, Usmani-Brown S, Clark P, Wilhelm JJ, Bellin MD, Herold KC, Mirmira RG, Dor Y, Evans-Molina C -
Mar 2020
Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.
DiabetesShapiro MR, Wasserfall CH, McGrail SM, Posgai AL, Bacher R, Muir A, Haller MJ, Schatz DA, Wesley JD, von Herrath M, Hagopian WA, Speake C, Atkinson MA, Brusko TM -
Feb 2020
Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype.
Sci ImmunolWen X, Yang J, James EA, Chow IT , Reijonen H , Kwok WW -
Feb 2020
Integrative network modeling reveals mechanisms underlying T cell exhaustion.
Sci RepBolouri H, Young M, Beilke J, Johnson R, Fox B, Huang L, Santini CC, Hill CM, Vries AVV, Shannon PT, Dervan A, Sivakumar P, Trotter M, Bassett D, Ratushny A -
Feb 2020
Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC.
Diabetes CareMishra R, Åkerlund M, Cousminer DL, Ahlqvist E, Bradfield JP, Chesi A, Hodge KM, Guy VC, Brillon DJ, Pratley RE, Rickels MR, Vella A, Ovalle F, Harris RI, Melander O, Varvel S, Hakonarson H, Froguel P, Lonsdale JT, Mauricio D, Schloot NC, Khunti K, Greenbaum CJ, Yderstræde KB, Tuomi T, Voight BF, Schwartz S, Boehm BO, Groop L, Leslie RD, Grant SFA -
Jan 2020
IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE.
JCI InsightLi D, Matta B, Song S, Nelson V, Diggins K, Simpfendorfer KR, Gregersen PK, Linsley PS, Barnes BJ -
Jan 2020
Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases.
Front ImmunolReeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JS -
Jan 2020
Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells.
ImmunohorizonsBerkson JD, Slichter CK, DeBerg HA, Delaney MA, Woodward-Davis AS, Maurice NJ, Lwo Y, Ko A, Hsu J, Chiu YW, Linsley PS, Dixon D, Prlic M -
Jan 2020
Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy.
Nat CommunSheih A, Voillet V, Hanafi LA, DeBerg HA, Yajima M, Hawkins R, Gersuk V, Riddell SR, Maloney DG, Wohlfahrt ME, Pande D, Enstrom MR, Kiem HP, Adair JE, Gottardo R, Linsley PS, Turtle CJ -
Jan 2020
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.
J Clin InvestWiedeman AE, Muir VS, Rosasco MG, DeBerg HA, Presnell S, Haas B, Dufort MJ, Speake C, Greenbaum CJ, Serti E, Nepom GT, Blahnik G, Kus AM, James EA, Linsley PS, Long SA -
Jan 2020
Stability and dynamics of the human gut microbiome and its association with systemic immune traits
bioRxivByrd AL, Liu M, Fujimura KE, Lyalina S, Nagarkar DR, Charbit B, Bergstedt J, Patin E, Harrison OJ, Quintana-Murci L, Duffy D, Albert ML, Milieu Intérieur Consortium. -
Jan 2020
Perioperative anaphylaxis in children: Etiology, time sequence, and patterns of clinical reactivity.
Pediatr Allergy ImmunolKhaleva E, Franz A, Garvey LH, Jay N, Ylescupidez A, Bahnson HT, Du Toit G -
Jan 2020
Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis.
J AutoimmunFree ME, Stember KG, Hess JJ, McInnis EA, Lardinois O, Hogan SL, Hu Y, Mendoza C, Le AK, Guseman AJ, Pilkinton MA, Bortone DS, Cowens K, Sidney J, Karosiene E, Peters B, James EA, Kwok WW, Vincent BG, Mallal SA, Jennette JC, Ciavatta DJ, Falk RJ -
Jan 2020
In-vivo assessment of T cell kinetics in individuals at risk for type 1 diabetes.
Clin Exp ImmunolHao W, Bahnson HT, Speake C, Cerosaletti K, Greenbaum CJ