Cancer: Disease Overview
Nearly 1.8 million Americans will learn that they have cancer this year. There are more than 200 forms of this often devastating disease, which are characterized by the uncontrolled and destructive growth of cells. Cancer is currently the second leading cause of death in the United States, and BRI is committed to finding out what causes it and how to better treat and prevent it.
Laboratory scientists are investigating the connections between autoimmune diseases and the mechanisms that help cancer grow and spread without being detected by the immune system. Clinical trials are studying cancer from a variety of angles, including prevention and treatment.
What Is Cancer?
Cancer is an umbrella term for a variety of diseases in which abnormal cells divide uncontrollably. These cells can invade nearby tissues and also spread to other parts of the body through the blood and lymph systems (known as metastasizing). Cancer can affect just about any part of the body. Biomedical advances over the past 50 years have vastly improved the treatments and outcomes for people facing cancer.
What Causes Cancer?
Cancer is caused by changes to genes that control the way cells function, especially the way they grow and divide. Usually, the immune system eliminates cells with damaged DNA. In the case of cancer, the immune system fails to recognize the cancerous cells and they can grow uncontrolled within the body.
What Are Risk Factors for Cancer?
Scientists still don’t know why one person develops cancer and another does not. However, research has shown that certain factors can increase a person’s chances of developing cancer.
- Age – Older people are more likely to develop cancer.
- Health habits – Smoking, drinking alcohol, obesity, excessive exposure to the sun and unsafe sex can all increase the chance of developing cancer.
- Family history – Though cancer is not passed down from one generation to the next, gene mutations that increase the risk of cancer can be. Not everyone who has a specific gene mutation will develop cancer.
- Health conditions – Some chronic conditions, such as ulcerative colitis, can increase the risk of cancer.
- Environmental exposures – Exposure to harmful chemicals, such as secondhand smoke, asbestos, benzene, etc., can increase the risk of cancer.
What Is the Latest Research Into Cancer?
BRI is a leader in understanding the interaction between immune system function and the development of cancer. Our current research includes:
- Unraveling how cancer cells stop the immune system from recognizing tumors as dangerous.
- Pinpointing the links between cancer and autoimmunity.
- Using artificial intelligence (AI) and data analytics to identify new targets for treatment.
- Understanding the cells and processes that allow cancer to advance.
Labs Studying Cancer
Buckner Lab
Byrd Lab
Linsley Lab
Stefani Lab
Ziegler Lab
Clinical Research Studies in Cancer
We have ongoing clinical research studies in several areas of cancer research. Studies labeled as “Enrolling” are actively accepting new participants while studies labeled as “Closed to Enrollment” are still active but no longer seeking new participants.
Please email Cancer Clinical Research or call (206) 287-6270 for more information.
- Bladder Cancer
A Randomized Phase III Trial of Intravesical BCG versus Intravesical Docetaxel and GEmcitabine Treatment in BCG Naïve High Grade Non-Muscle Invasive Bladder Cancer (BRIDGE)
Principal Investigator: Huong Pham, MD
Status: EnrollingDoes the use of a post-operative pedometer impact the return of bowel function and narcotic use following radical cystectomy?
Principal Investigator: Alvaro Lucioni, MD
Status: EnrollingAdjuvant study of MK-3475 (Pembrolizumab) in muscle invasive and locally advanced urothelial carcinoma (Ambassador) versus observation
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment- Blood Cancer
A Phase 3, Multicenter, Randomized, Open-Label Trial to Evaluate the Safety and Efficacy of Epcoritamab + Rituximab and Lenalidomide (R2) Compared to Chemoimmunotherapy in Previously Untreated Follicular Lymphoma (EPCORE™FL-2)
Principal Investigator: David Aboulafia, MD
Status: EnrollingA Phase II Trial of PET-Directed Therapy for Limited Stage Diffuse Large B-Cell Lymphoma (DLBCL)
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Randomized, Open-label, Phase 3 Trial of A+AVD versus ABVD as Frontline Therapy in Patients with Advanced Classical Hodgkin Lymphoma
Principal Investigator: David Aboulafia, MD
Status: Closed to EnrollmentSWOG S0016 A Phase III Trial of CHOP Plus Rituximab versus CHOP Plus Iodine-131-Labeled Monoclonal Anti-B1 Antibody (Tositumomab) for the Treatment of Newly Diagnosed Follicular Non-Hodgkin’s Lymphoma
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment- Brain Cancer
A Multicenter Observational Study of GammaTile™ Surgically Targeted Radiation Therapy (STaRT) in Intracranial Brain Neoplasms Short Title: STaRT
Principal Investigator: Huong Pham, MD
Status: EnrollingA Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT) versus Surgically Targeted Radiation Therapy (STaRT) with Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors.
Principal Investigator: Huong Pham, MD
Status: EnrollingLomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in MGMT+ GBM
Principal Investigator: John Paul Flores, MD
Status: EnrollingRandomized trial of veliparib or placebo in combination with adjuvant temozolomide in newly diagnosed GBM with MGMT promoter hypermethylation
Principal Investigator: John Paul Flores, MD
Status: Closed to Enrollment- Breast Cancer
A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women with Hormone Receptor Positive Breast Cancer
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Phase 3, Randomized, Open-Label, Multicenter Trial of Arv-471 Vs Fulvestrant in Participants with Estrogen Receptor-Positive, Her2-Negative Advanced Breast Cancer Whose Disease Progressed After Prior Endocrine Based Treatment for Advanced Disease
Principal Investigator: Meaghan O'Malley, MD
Status: Closed to EnrollmentA PHASE III CLINICAL TRIAL COMPARING TRASTUZUMAB GIVEN CONCURRENTLY WITH RADIATION THERAPY AND RADIATION THERAPY ALONE FOR WOMEN WITH HER2-POSITIVE DUCTICAL CARCINOMA IN SITU RESECTED BY LUMPECTOMY
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Phase III Trial of Accelerated Whole Breast Irradiation with Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA RANDOMIZED, PHASE III TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF MK-3475 (PEMBROLIZUMAB) AS ADJUVANT THERAPY FOR TRIPLE RECEPTOR-NEGATIVE BREAST CANCER WITH ≥ 1 CM RESIDUAL INVASIVE CANCER OR POSITIVE LYMPH NODES (ypN+) AFTER NEOADJUVANT CHEMOTHERAPY
Principal Investigator: Meaghan O'Malley, MD
Status: Closed to EnrollmentIntra-Operative Radiotherapy after breast conserving therapy in the treatment of early stage breast cancer
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentPhase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk Hormone Receptor-Positive and Her2/Neu Negative Breast Cancer
Principal Investigator: Nanette Robinson, MD
Status: Closed to Enrollment- Cancer Non-Specific
A prospective observational cohort study to assess miRNA 371 for outcome prediction in patients with newly diagnosed germ cell tumors
Principal Investigator: John Paul Flores, MD
Status: EnrollingEA2197: Optimal Perioperative Therapy For Incidental Gallbladder Cancer (OPT-IN): A Randomized Phase II/III TrialEA2197: Optimal Perioperative Therapy For Incidental Gallbladder Cancer (OPT-IN): A Randomized Phase II/III Trial
Principal Investigator: Bruce Lin, MD
Status: EnrollingVirginia Mason Medical Center and Benaroya Research Institute Tumor Tissue Repository (VM-BRITE) Sample Collection Protocol
Principal Investigator: Christopher Gault, MD
Status: EnrollingCharacterization of the peripheral blood signature in patients treated with PD1/PDL-1 Checkpoint Inhibitors
Principal Investigator: John Paul Flores, MD
Status: Closed to EnrollmentPhase III Trial of Radiotherapy Plus Cetuximab versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentProgram for the assessment of clinical cancer tests (PACCT-1): Trial assigning individualized options for treatment: The TAILORx Trial
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment- Colorectal Cancer
A multi-site, open-label, Phase II, randomized, controlled trial to compare the efficacy of RO7198457 versus watchful waiting in resected, Stage II (high risk) and Stage III colorectal cancer patients who are ctDNA positive following resection
Principal Investigator: Bruce Lin, MD
Status: EnrollingA Phase 2, Randomized, Open-label Study of Onvansertib in Combination with FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-line Treatment of Metastatic Colorectal Cancer in Patients with a KRAS or NRAS Mutation
Principal Investigator: Bruce Lin, MD
Status: EnrollingA PHASE 3 RANDOMIZED TRIAL OF NEOADJUVANT CHEMOTHERAPY, EXCISION AND OBSERVATION VERSUS CHEMORADIOTHERAPY FOR EARLY RECTAL CANCER
Principal Investigator: Huong Pham, MD
Status: EnrollingHAI Consortium Research Network: Registry of Hepatic Arterial Infusion (HAI)
Principal Investigator: Lauren Wancata, MD
Status: EnrollingThe Janus Rectal Cancer Trial: A Randomized Phase II/III Trial Testing the Efficacy of Triplet Versus Doublet Chemotherapy Regarding Clinical Complete Response and Disease-free Survival in Patients with Locally Advanced Rectal Cancer
Principal Investigator: Val Simianu, MD
Status: EnrollingA Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients with Stage 0-III Colon or Rectal Cancer, Phase III –Preventing Adenomas of the Colon with Eflornithine and Sulindac (PACES)
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Phase II/III Trial of Neoadjuvant FOLFOX with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Under
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Pilot Protocol Evaluating Safety of the Medtronic Pump and Codman Catheter for the Delivery of Hepatic Arterial Infusion (HAI) Chemotherapy in patients with advanced Colorectal Carcinoma or Cholangiocarcinoma
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Randomized Open-Label Phase 3 Study of XL092 + Atezolizumab vs Regorafenib in Subjects with Metastatic Colorectal Cancer
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentNEOADJUVANT CHEMOTHERAPY, EXCISION AND OBSERVATION FOR EARLY RECTAL CANCER | The NEO Trial.
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentRandomized trial of standard chemotherapy alone or combined with Atezolizumab as adjuvant therapy for patients with Stage III colon cancer and deficient DNA mismatch repair.
Principal Investigator: Bruce Lin, MD
Status: Closed to Enrollment- Gastroesophageal Cancer
A Phase 2 Study of Futibatinib in Combination with PD-1 Antibody-based Standard of Care Therapy in Patients with Solid Tumors
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo in Subjects with Resected Esophageal, or Gastroesophageal Junction Cancer
Principal Investigator: Bruce Lin, MD
Status: Closed to Enrollment
Evaluation of the Lasting Symptoms After Esophageal Resection (LASER) questionnaire in esophageal disease
Principal Investigator: Donald Low, MD
Status: Closed to EnrollmentInfluence of Nutrition and SarcoPenia on Esophageal Cancer outcomes (INSPECT study)
Principal Investigator: Donald Low, MD
Status: Closed to EnrollmentPhase 2 study of ZW25 plus first-line combination chemotherapy in HER2-Expression gastroesophageal adenocarcinoma (GEA)
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentTemporal variation in exhaled volatile organic compounds in response to therapeutic intervention in esophageal cancer patients
Principal Investigator: Donald Low, MD
Status: Closed to Enrollment- Gynecologic Cancer
REFRaME-O1: A Phase 2/3 Open-label Study Evaluating the Efficacy and Safety of Luveltamab Tazevibulin (STRO-002) versus Investigator’s Choice (IC) Chemotherapy in Women with Relapsed Platinum-resistant Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing Folate Receptor Alpha (FOLR1)
Principal Investigator: Allison Barrie, MD
Status: EnrollingCAN DIET AND EXERCISE MODULATE OVARIAN, FALLOPIAN TUBE AND PRIMARY PERITONEAL CANCER PROGRESSION-FREE SURVIVAL?
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment- Hepatobiliary Cancer (Liver and Biliary Tract)
A PHASE 1 DOSE ESCALATION AND COHORT EXPANSION STUDY OF TSR-022, AN ANTI-TIM-3 MONOCLONAL ANTIBODY, IN PATIENTS WITH ADVANCED SOLID TUMORS (AMBER)
Principal Investigator: Bruce Lin, MD
Status: EnrollingA Phase 1b/2 Multicenter, Open-label Study to Evaluate the Safety and Efficacy of TTI-101 as Monotherapy and in Combination in Participants with Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
Principal Investigator: Bruce Lin, MD
Status: EnrollingA PHASE II, OPEN-LABEL, MULTI-COHORT, MULTICENTER STUDY IN PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA AND CHILD-PUGH B7 AND B8 CIRRHOSIS
Principal Investigator: Bruce Lin, MD
Status: EnrollingALTUS: PERFORMANCE OF A MULTI-TARGET HEPATOCELLULAR CARCINOMA (HCC) TEST IN SUBJECTS WITH INCREASED RISK
Principal Investigator: Asma Siddique, MD
Status: EnrollingA First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY 4008, in Patients With Intrahepatic Cholangiocarcinoma (ICC) and Other Advanced Solid Tumors
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Phase 1 Dose-escalation Study of FF-10832 for the Treatment of Advanced Solid Tumors
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Phase 2/3 Randomized, Controlled Study of CTX-009 in Combination with Paclitaxel versus Paclitaxel Alone in Adult Patients with Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers who have received One Prior Systemic Chemotherapy Regimen
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation (KEYNOTE-937)
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Phase 3, Open-Label, Randomized, Active-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Gemcitabine Plus Cisplatin Chemotherapy in First-Line Treatment of Participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement (FIGHT-302)
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING ATEZOLIZUMAB AND BEVACIZUMAB, WITH OR WITHOUT TIRAGOLUMAB, IN PATIENTS WITH UNTREATED LOCALLY ADVANCED OR METASTATIC HEPATOCELLULAR CARCINOMA
Principal Investigator: Bruce Lin, MD
Status: Closed to EnrollmentA Single Arm Phase Ib/II Multi-Center Study of Nivolumab in Combination with nanoliposomal-Irinotecan, 5-Fluorouracil, and Leucovorin as Second Line Therapy for Patients with Advanced Biliary Tract Cancer
Principal Investigator: Bruce Lin, MD
Status: Closed to Enrollment- HIV/AIDS Malignancies
AMC-101, A Pilot Study of Ibrutinib and R-da-EPOCH for Front Line Treatment of AIDS-Related Lymphomas
Principal Investigator: David Aboulafia, MD
Status: EnrollingImpact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living with HIV: A Feasibility Study
Principal Investigator: David Aboulafia, MD
Status: EnrollingUse of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AIDS Malignancy Consortium
Principal Investigator: David Aboulafia, MD
Status: EnrollingA Phase I Study of Ipilimumab and Nivolumab in Advanced HIV-Associated Solid Tumors with Expansion Cohorts in HIV-Associated Solid Tumors and a Cohort of HIV-Associated Classical Hodgkin Lymphoma
Principal Investigator: David Aboulafia, MD
Status: Closed to EnrollmentANCHOR: Anal Cancer/HSIL Outcomes Research Study
Principal Investigator: David Aboulafia, MD
Status: Closed to EnrollmentClinical and Genomic Factors for Prognosis of AIDS Primary Effusion Lymphoma
Principal Investigator: David Aboulafia, MD
Status: Closed to Enrollment- Kaposi Sarcoma
A Phase 2 Trial of Ixazomib for Kaposi Sarcoma
Principal Investigator: David Aboulafia, MD
Status: EnrollingMulticenter Phase II Study of Pomalidomide Monotherapy in Kaposi Sarcoma
Principal Investigator: David Aboulafia, MD
Status: EnrollingA Phase II Study of sEphB4-HAS in Kaposi Sarcoma
Principal Investigator: David Aboulafia, MD
Status: Closed to EnrollmentA Pilot Study of Nelfinavir for the Treatment of Kaposi Sarcoma: A Trial of the AIDS Malignancy Consortium (AMC)
Principal Investigator: David Aboulafia, MD
Status: Closed to Enrollment- Kidney Cancer
EVEREST EVErolimus for Renal Cancer Ensuing Surgical Therapy, a Phase III Study
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment- Lung Cancer
A Phase II Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib Versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK)
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment- Neuroendocrine Tumors
An International, Non-Interventional, Post-Authorization Long-Term Safety Study of Lutathera®, in Patients with Unresectable or Metastatic, Well-Differentiated, Somatostatin Receptor Positive, Gastroenteropancreatic Neuroendocrine Tumours (SALUS study).
Principal Investigator: Bruce Lin, MD
Status: EnrollingRandomized, double-blinded phase III study of cabozantinib versus placebo in patients with advanced neuroendocrine tumors after progression on everolimus (CABINET)
Principal Investigator: Bruce Lin, MD
Status: Closed to Enrollment- Pancreatic Cancer
A Phase 1 Open-label Study to Assess the Safety and Tolerability of Zolbetuximab (IMAB362) in Combination with Chemotherapy (mFOLFIRINOX) in Participants with CLDN18.2 Positive Metastatic Pancreatic Adenocarcinoma
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingA Phase 1/1b Study of ASP2138 in Participants with Metastatic or Locally Advanced Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma or Metastatic Pancreatic Adenocarcinoma Whose Tumors Have Claudin (CLDN) 18.2 Expression
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingA Phase 1b Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of ATP150/ATP152, VSV-GP154 and Ezabenlimab (BI 754091) in Patients with KRAS G12D/G12V Mutated Pancreatic Ductal Adenocarcinoma
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingA Phase 1b/2a Study of Gemcitabine and Nab-paclitaxel in Combination with Avutometinib (VS-6766) and Defactinib in Patients with Previously Untreated Metastatic Adenocarcinoma of the Pancreas
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingA Phase 2, Randomized, Open-Label, Controlled Study to Evaluate the Efficacy and Safety of Ampligen® Compared to Control Group / No Treatment Following FOLFIRINOX in Subjects with Locally Advanced Pancreatic Adenocarcinoma
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingA Phase I/II Study of MCLA-128, a full length IgG1 Bispecific Antibody Targeting HER2 and HER3, in Patients with Solid Tumors
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingAlternating neoadjuvant Gemcitabine-Nab-Paclitaxel and nal-IRI with 5-Fluorouracil and folinic acid (Leucovorin) regimens in resectable and borderline resectable pancreatic cancer, A Pilot Study
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingAnalysis of Health Outcome of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer
Principal Investigator: Vincent Picozzi, MD
Status: EnrollingA Phase 2, Open-Label, Randomized Study to Assess the Efficacy and Safety of Zolbetuximab (IMAB362) in Combination with Nab-Paclitaxel and Gemcitabine (Nab P + GEM) as First Line Treatment in Subjects with Claudin 18.2 (CLDN18.2) Positive, Metastatic Pancreatic Adenocarcinoma
Principal Investigator: Vincent Picozzi, MD
Status: Closed to EnrollmentPANOVA-3: Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields, 150kHz) concomitant with gemcitabine and nab-paclitaxel for front-line treatment of locally-advanced pancreatic adenocarcinoma
Principal Investigator: Vincent Picozzi, MD
Status: Closed to EnrollmentPRECISION PROMISE PLATFORM TRIAL FOR METASTATIC PANCREATIC CANCER
Principal Investigator: Vincent Picozzi, MD
Status: Closed to EnrollmentVM-BRI repository for early detection of pancreas cancer (VM-BRIDPAN)
Principal Investigator: Margaret Mandelson, PhD
Status: Closed to Enrollment- Prostate Cancer
A Phase 2 Open-label Extension Study for Subjects with Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
Principal Investigator: John Paul Flores, MD
Status: EnrollingNRG-GU009: PARALLEL PHASE III RANDOMIZED TRIALS FOR HIGH RISK PROSTATE CANCER EVALUATING DE-INTENSIFICATION FOR LOWER GENOMIC RISK AND INTENSIFICATION OF CONCURRENT THERAPY FOR HIGHER GENOMIC RISK WITH RADIATION (PREDICT-RT*)
Principal Investigator: Huong Pham, MD and John Paul Flores, MD
Status: EnrollingNRG-GU010: PARALLEL PHASE III RANDOMIZED TRIALS OF GENOMIC-RISK STRATIFIED UNFAVORABLE INTERMEDIATE RISK PROSTATE CANCER: DE-INTENSIFICATION AND INTENSIFICATION CLINICAL TRIAL EVALUATION (GUIDANCE)
Principal Investigator: Huong Pham, MD and John Paul Flores, MD
Status: EnrollingA Multicenter, Randomized, Double-Blind, Placebo-Controlled,Phase III Study of ARN-509 in Men with Non-Metastatic (M0) Castration-Resistant Prostate Cancer
Principal Investigator: Joseph Rosales, MD
Status: Closed to EnrollmentA Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA PHASE III TRIAL OF SHORT TERM ANDROGEN DEPRIVATION WITH PELVIC LYMPH NODE OR PROSTATE BED ONLY RADIOTHERAPY (SPPORT) IN PROSTATE CANCER PATIENTS WITH A RISING PSA AFTER RADICAL PROSTATECTOMY.
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentA Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate Radical Prostatectomy in Patients with High-Risk, Clinically Localized Prostate Cancer
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentAndrogen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentCHAARTED: ChemoHormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer
Principal Investigator: Huong Pham, MD
Status: Closed to EnrollmentDoes the Use of a Post-Operative Pedometer Affect Rate of Return of Bowel Function and Narcotic Use Following Radical Prostatectomy
Principal Investigator: Una Lee, MD
Status: Closed to EnrollmentPhase III IGRT and SBRT vs IGRT and Hypofractionated IMRT for localized intermediate risk prostate cancer
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment- Skin Cancer
A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-risk Melanoma
Principal Investigator: Huong Pham, MD
Status: Closed to Enrollment