Faculty & Scientific Staff
Jane Buckner, MD
Background Information
Jane Buckner is the President of the Benaroya Research Institute, an affiliate Professor at the University of Washington and practicing rheumatologist. She is known for her research in translational immunology, combining genetics, immunology and clinical medicine to advance the understanding of the causes of autoimmune diseases. At the Benaroya Research Institute, Dr. Buckner was instrumental in developing the translational immunology research program and establishing the BRI biorepository, which currently includes more than 350,000 samples from 14,000 participants. Dr. Buckner has made significant contributions to our understanding of how human T cells are dysregulated in type 1 diabetes and rheumatoid arthritis and has been a pioneer in the development of antigen-specific Treg therapies. Dr. Buckner is the inaugural holder of the Gerald Nepom Endowed Chair at BRI. She also leads the Coordinating Center of the Immune Tolerance Network, an NIH funded collaborative network for clinical research, and is a scientific advisor for Type 1 Diabetes TrialNet, an NIH-funded clinical trial network for type 1 diabetes prevention and early treatment. She is the current chair of the NIH/NIAMS Board of Scientific Counselors and served as the chair of the NIH/NIAID Cooperative Study Group for Autoimmune Disease Prevention. Dr. Buckner received her bachelor’s degree in chemistry from Carleton College, her MD from Johns Hopkins School of Medicine, her residency in Internal Medicine at University of Minnesota and a rheumatology fellowship at the University of Washington. Dr. Buckner has received multiple awards including the American College of Rheumatology Arthritis Investigator Award and is the 2024 recipient of the American Association of Immunologists Steinman Award for Human Immunology Research.
Featured Publications
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Oct 2022
IL-6-targeted therapies directed to cytokine or receptor blockade drive distinct alterations in T cell function.
JCI InsightSpeake C, Habib T, Lambert K, Hundhausen C, Lord S, Dufort MJ, Skinner SO, Hu A, Kinsman M, Jones BE, Maerz MD, Tatum M, Hocking AM, Nepom GT, Greenbaum CJ, Buckner JH -
Oct 2022
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.
Sci Transl MedYang SJ, Singh AK, Drow T, Tappen T, Honaker Y, Barahmand-Pour-Whitman F, Linsley PS, Cerosaletti K, Mauk K, Xiang Y, Smith J, Mortensen E, Cook PJ, Sommer K, Khan I, Liggitt D, Rawlings DJ, Buckner JH -
Jul 2022
IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation.
Front ImmunolLambert K, Diggins KE, Jones BE, Hundhausen C, Maerz MD, Hocking AM, Sanda S, Greenbaum CJ, Linsley PS, Cerosaletti K, Buckner JH -
Feb 2022
Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes.
J ImmunolJones BE, Maerz MD, Bahnson HT, Somasundaram A, McCarthy LH, Speake C, Buckner JH -
Mar 2021
Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis.
JCI InsightSong J, Schwenzer A, Wong A, Turcinov S, Rims C, Martinez LR, Arribas-Layton D, Gerstner C, Muir VS, Midwood KS, Malmström V, James EA, Buckner JH