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FRTX-02, a selective and potent inhibitor of DYRK1A, modulates inflammatory pathways in mouse models of psoriasis and atopic dermatitis.
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Plasma Interleukin-6 Predicts Clinical Decline After Completion of Dexamethasone Therapy in Severe COVID-19.
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Defining the window of opportunity and the target populations to prevent peanut allergy.
J Allergy Clin ImmunolRoberts G, Bahnson HT, Du Toit G, O'Rourke C, Sever ML, Brittain E, Plaut M, Lack G -
Omics-Oriented Research illustrated with the LEAP Study and the OASIS Bioinformatics Tool.
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Epitope-Specific IgE at 1 Year of Age Can Predict Peanut Allergy Status at 5 Years.
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A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice.
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Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells.
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Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses.
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Inflammatory bone marrow signaling in pediatric acute myeloid leukemia distinguishes patients with poor outcomes.
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HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success.
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Epidermal Differentiation Complex Genetic Variation in Atopic Dermatitis and Peanut Allergy.
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In children with eczema, expansion of epitope-specific IgE is associated with peanut allergy at 5 years of age.
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HLA-DR3 restricted environmental epitopes from the bacterium Clostridium tetani have T cell cross-reactivity to the SLE-related autoantigen SmD.
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Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum.
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IL-6-targeted therapies directed to cytokine or receptor blockade drive distinct alterations in T cell function.
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