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Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.
Journal of ImmunologyDoherty DG, Penzotti JE, Koelle DM, Kwok WW, Lybrand TP, Masewicz S, Nepom GT -
Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions.
Journal of VirologyKoelle DM, Frank JM, Johnson ML, Kwok WW -
Molecular basis for HLA-DQ associations with IDDM.
DiabetesNepom GT, Kwok WW -
Novel glycosylation of HLA-DRalpha disrupts antigen presentation without altering endosomal localization.
J ImmunolGuerra CB, Busch R, Doebele RC, Liu W, Sawada T, Kwok WW, Chang MD, Mellins ED -
A peptide binding motif for HLA-DQA1*0102/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus.
Journal of ImmunologyEttinger RA, Kwok WW -
Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201.
Human ImmunologyKoelle DM, Johnson ML, Ekstrom AN, Byers P, Kwok WW -
Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.
Journal of ImmunologyBuckner JH, Kwok WW, Nepom BS, Nepom GT -
Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules.
PNAS USANepom BS, Nepom GT, Coleman M, Kwok WW -
Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase.
Journal of ImmunologyKwok WW, Domeier ML, Raymond FC, Byers P, Nepom GT -
HLA-DQB1 codon 57 is critical for peptide binding and recognition.
The Journal of Experimental MedicineKwok WW, Domeier ME, Johnson ML, Nepom GT, Koelle DM -
HLA-DQ polymorphisms are highly selective for peptide binding interactions.
Journal of ImmunologyKwok WW, Nepom GT, Raymond FC -
Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome.
The Journal of Clinical InvestigationKovats S, Nepom GT, Coleman M, Nepom BS, Kwok WW, Blum JS -
Human class II major histocompatibility complex gene transfer into murine neuroblastoma leads to loss of tumorigenicity, immunity against subsequent tumor challenge, and elimination of microscopic preestablished tumors.
Journal of Immunotherapy with Emphasis on Tumor ImmunologyHock RA, Reynolds BD, Tucker-McClung CL, Kwok WW -
Expression from leukocyte integrin promoters in retroviral vectors.
Human Gene TherapyBauer TR Jr, Osborne WR, Kwok WW, Hickstein DD -
Amino acids in the peptide-binding groove influence an antibody-defined, disease-associated HLA-DR epitope.
Scandinavian Journal of ImmunologyDrover S, Marshall WH, Kwok WW, Nepom GT, Karr RW
