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Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset.
International ImmunologyNovak EJ, Masewicz SA, Liu AW, Lernmark A, Kwok WW, Nepom GT -
Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens.
Journal of ImmunologyNovak EJ, Liu AW, Gebe JA, Falk BA, Nepom GT, Koelle DM, Kwok WW -
CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells.
Journal of ImmunologyKoelle DM, Chen HB, Gavin MA, Wald A, Kwok WW, Corey L -
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin.
The Journal of Clinical InvestigationAlleva DG, Crowe PD, Jin L, Kwok WW, Ling N, Gottschalk M, Conlon PJ, Gottlieb PA, Putnam AL, Gaur A -
Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response.
Journal of ImmunologyReichstetter S, Ettinger RA, Liu AW, Gebe JA, Nepom GT, Kwok WW -
Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans.
Journal of VirologyKoelle DM, Reymond SN, Chen H, Kwok WW, McClurkan C, Gyaltsong T, Petersdorf EW, Rotkis W, Talley AR, Harrison DA -
Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus.
Journal of ImmunologyEttinger RA, Liu AW, Nepom GT, Kwok WW -
Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer.
Human ImmunologyParsons KT, Kwok WW, Gaur LK, Nepom GT -
HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells.
Journal of ImmunologyKwok WW, Liu AW, Novak EJ, Gebe JA, Ettinger RA, Nepom GT, Reymond SN, Koelle DM -
Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor.
J VirolHaan KM, Kwok WW, Longnecker R, Speck P -
MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen.
The Journal of Clinical InvestigationNovak EJ, Liu AW, Nepom GT, Kwok WW -
Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition.
Human ImmunologyKwok WW, Reijonen H, Falk BA, Koelle DM, Nepom GT -
MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition.
Human ImmunologyReichstetter S, Kwok WW, Kochik S, Koelle DM, Beaty JS, Nepom GT -
Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer.
Tissue AntigensReichstetter S, Kwok WW, Nepom GT -
Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.
Journal of ImmunologyEttinger RA, Liu AW, Nepom GT, Kwok WW
