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HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells.
J ImmunolKwok WW, Liu AW, Novak EJ, Gebe JA, Ettinger RA, Nepom GT, Reymond SN, Koelle DM -
Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor.
J VirolHaan KM, Kwok WW, Longnecker R, Speck P -
MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen.
J Clin InvestNovak EJ, Liu AW, Nepom GT, Kwok WW -
Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition.
Hum ImmunolKwok WW, Reijonen H, Falk BA, Koelle DM, Nepom GT -
MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition.
Hum ImmunolReichstetter S, Kwok WW, Kochik S, Koelle DM, Beaty JS, Nepom GT -
Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer.
Tissue AntigensReichstetter S, Kwok WW, Nepom GT -
Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.
J ImmunolEttinger RA, Liu AW, Nepom GT, Kwok WW -
Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.
J ImmunolDoherty DG, Penzotti JE, Koelle DM, Kwok WW, Lybrand TP, Masewicz S, Nepom GT -
Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions.
J VirolKoelle DM, Frank JM, Johnson ML, Kwok WW -
Molecular basis for HLA-DQ associations with IDDM.
DiabetesNepom GT, Kwok WW -
Novel glycosylation of HLA-DRalpha disrupts antigen presentation without altering endosomal localization.
J ImmunolGuerra CB, Busch R, Doebele RC, Liu W, Sawada T, Kwok WW, Chang MD, Mellins ED -
A peptide binding motif for HLA-DQA1*0102/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus.
J ImmunolEttinger RA, Kwok WW -
Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201.
Hum ImmunolKoelle DM, Johnson ML, Ekstrom AN, Byers P, Kwok WW -
Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.
J ImmunolBuckner JH, Kwok WW, Nepom BS, Nepom GT -
Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules.
Proc Natl Acad Sci U S ANepom BS, Nepom GT, Coleman M, Kwok WW
