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    • Feb 2024

      Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology.

      medRxiv
      Van Phan H, Tsitsiklis A, Maguire CP, Haddad EK, Becker PM, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, van Zalm P, Altman MC, Augustine AD, Calfee CS, Bosinger S, Cairns C, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N, IMPACC Network, Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Diray-Arce J, Langelier CR
    • Jan 2024

      IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.

      Nat Commun
      Haslund-Gourley BS, Woloszczuk K, Hou J, Connors J, Cusimano G, Bell M, Taramangalam B, Fourati S, Mege N, Bernui M, Altman MC, Krammer F, van Bakel H, IMPACC Network, Maecker HT, Rouphael N, Diray-Arce J, Wigdahl B, Kutzler MA, Cairns CB, Haddad EK, Comunale MA
    • Jan 2024

      Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.

      Nat Commun
      Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, Dandekar R, Shannon CP, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Sesma AF, Simon V, van Bakel H, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS, Erle DJ, Langelier CR, Eckalbar W, Bosinger SE, IMPACC Network, Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC, Montgomery RR, Becker PM, Rouphael N
    • Nov 2023

      Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants.

      bioRxiv
      Gygi JP, Maguire C, Patel RK, Shinde P, Konstorum A, Shannon CP, Xu L, Hoch A, Jayavelu ND, Network I, Haddad EK, Reed EF, Kraft M, McComsey GA, Metcalf J, Ozonoff A, Esserman D, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen LB, van Bakel H, Wilson M, Eckalbar W, Maecker H, Langelier CR, Steen H, Altman MC, Montgomery RR, Levy O, Melamed E, Pulendran B, Diray-Arce J, Smolen KK, Fragiadakis GK, Becker PM, Augustine AD, Sekaly RP, Ehrlich LIR, Fourati S, Peters B, Kleinstein SH, Guan L
    • Oct 2023

      Protective mechanisms of allergic asthma in COVID-19.

      J Allergy Clin Immunol
      Doni Jayavelu N, Jackson DJ, Altman MC
    • Sep 2023

      Molecular pathways underlying lung-brain axis signaling in asthma: relevance for psychopathology and neuroinflammation.

      J Allergy Clin Immunol
      Dill-McFarland KA, Altman MC, Esnault S, Jarjour NN, Busse WW, Rosenkranz MA
    • Jul 2023

      Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy.

      J Allergy Clin Immunol
      Altman MC, Segnitz RM, Larson D, Jayavelu ND, Smith M, Patel S, Scadding GW, Qin T, Sanda S, Steveling E, Eifan AO, Penagos M, Jacobson MR, Parkin RV, Shamji MH, Togias A, Durham SR
    • May 2023

      Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients.

      Cell Rep Med
      Diray-Arce J, Fourati S, Doni Jayavelu N, Patel R, Maguire C, Chang AC, Dandekar R, Qi J, Lee BH, van Zalm P, Schroeder A, Chen E, Konstorum A, Brito A, Gygi JP, Kho A, Chen J, Pawar S, Gonzalez-Reiche AS, Hoch A, Milliren CE, Overton JA, Westendorf K, IMPACC Network, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen L, Grubaugh ND, van Bakel H, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier CR, Levy O, Altman MC, Maecker H, Montgomery RR, Haddad EK, Sekaly RP, Esserman D, Ozonoff A, Becker PM, Augustine AD, Guan L, Peters B, Kleinstein SH
    • May 2023

      Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma.

      Am J Respir Crit Care Med
      Murphy RC, Lai Y, Liu M, Al-Shaikhly T, Altman MC, Altemeier WA, Frevert CW, Debley JS, Piliponsky AM, Ziegler SF, Gharib SA, Hallstrand TS
    • May 2023

      kimma: flexible linear mixed effects modeling with kinship covariance for RNA-seq data.

      Bioinformatics
      Dill-McFarland KA, Mitchell K, Batchu S, Segnitz RM, Benson B, Janczyk T, Cox MS, Mayanja-Kizza H, Boom WH, Benchek P, Stein CM, Hawn TR, Altman MC
    • Mar 2023

      Type-2 inflammation reduces SARS-CoV-2 replication in the airway epithelium in allergic asthma through functional alteration of ciliated epithelial cells.

      J Allergy Clin Immunol
      Doni Jayavelu N, Altman MC, Benson B, Dufort M, Vanderwall ER, Rich LM, White MP, Becker PM, Togias A, Jackson DJ, Debley JS
    • Mar 2023

      Airway Transcriptome Networks Identify Susceptibility to Frequent Asthma Exacerbations in Children.

      J Allergy Clin Immunol
      Phelan KJ, Dill-McFarland KA, Kothari A, Segnitz RM, Burkle J, Grashel B, Jenkins S, Spagna D, Martin LJ, Haslam DB, Biagini JM, Kalra M, McCoy KS, Ross KR, Jackson DJ, Mersha T, Altman MC, Hershey GKK
    • Mar 2023

      What Have Mechanistic Studies Taught Us About Childhood Asthma?

      J Allergy Clin Immunol Pract
      Laubhahn K, Phelan KJ, Jackson DJ, Altman MC, Schaub B
    • Feb 2023

      A Functional Genomics Pipeline to Identify High-Value Asthma and Allergy CpGs in the Human Methylome.

      J Allergy Clin Immunol
      Morin A, Thompson EE, Helling BA, Shorey-Kendrick LE, Faber P, Gebretsadik T, Bacharier LB, Kattan M, O'Connor GT, Rivera-Spoljaric K, Wood RA, Barnes KC, Mathias RA, Altman MC, Hansen K, McEvoy CT, Spindel ER, Hartert T, Jackson DJ, Gern JE, McKennan CG, Ober C, program collaborators for Environmental Influences on Child Health Outcomes and Children’s Respiratory and Environmental Workgroup
    • Jan 2023

      Rhinovirus infection of the airway epithelium enhances mast cell immune responses via epithelial-derived interferons.

      J Allergy Clin Immunol
      Murphy RC, Lai Y, Altman MC, Barrow KA, Dill-McFarland KA, Liu M, Hamerman JA, Lacy-Hulbert A, Piliponsky AM, Ziegler SF, Altemeier WA, Debley JS, Gharib SA, Hallstrand TS

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Benaroya Research Institute

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