-
Mar 2023
Type-2 inflammation reduces SARS-CoV-2 replication in the airway epithelium in allergic asthma through functional alteration of ciliated epithelial cells.
J Allergy Clin ImmunolDoni Jayavelu N, Altman MC, Benson B, Dufort M, Vanderwall ER, Rich LM, White MP, Becker PM, Togias A, Jackson DJ, Debley JS -
Mar 2023
Airway Transcriptome Networks Identify Susceptibility to Frequent Asthma Exacerbations in Children.
J Allergy Clin ImmunolPhelan KJ, Dill-McFarland KA, Kothari A, Segnitz RM, Burkle J, Grashel B, Jenkins S, Spagna D, Martin LJ, Haslam DB, Biagini JM, Kalra M, McCoy KS, Ross KR, Jackson DJ, Mersha T, Altman MC, Hershey GKK -
Feb 2023
A Functional Genomics Pipeline to Identify High-Value Asthma and Allergy CpGs in the Human Methylome.
J Allergy Clin ImmunolMorin A, Thompson EE, Helling BA, Shorey-Kendrick LE, Faber P, Gebretsadik T, Bacharier LB, Kattan M, O'Connor GT, Rivera-Spoljaric K, Wood RA, Barnes KC, Mathias RA, Altman MC, Hansen K, McEvoy CT, Spindel ER, Hartert T, Jackson DJ, Gern JE, McKennan CG, Ober C, program collaborators for Environmental Influences on Child Health Outcomes and Children’s Respiratory and Environmental Workgroup -
Jan 2023
Rhinovirus infection of the airway epithelium enhances mast cell immune responses via epithelial-derived interferons.
J Allergy Clin ImmunolMurphy RC, Lai Y, Altman MC, Barrow KA, Dill-McFarland KA, Liu M, Hamerman JA, Lacy-Hulbert A, Piliponsky AM, Ziegler SF, Altemeier WA, Debley JS, Gharib SA, Hallstrand TS -
Jan 2023
Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis.
Lancet Planet HealthAltman MC, Kattan M, O'Connor GT, Murphy RC, Whalen E, LeBeau P, Calatroni A, Gill MA, Gruchalla RS, Liu AH, Lovinsky-Desir S, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Teach SJ, Bacharier LB, Wheatley LM, Sigelman SM, Gergen PJ, Togias A, Busse WW, Gern JE, Jackson DJ, National Institute of Allergy and Infectious Disease's Inner City Asthma Consortium -
Oct 2022
Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: a randomized controlled trial.
J Allergy Clin ImmunolCorren J, Larson D, Altman MC, Segnitz RM, Avila PC, Greenberger PA, Baroody F, Moss MH, Nelson H, Burbank AJ, Hernandez ML, Peden D, Saini S, Tilles S, Hussain I, Whitehouse D, Qin T, Villarreal M, Sever M, Wheatley LM, Nepom GT, Sanda S, Immune Tolerance Network ITN057AD CATNIP Study Team. -
Sep 2022
African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Genome MedWashington C 3rd, Dapas M, Biddanda A, Magnaye KM, Aneas I, Helling BA, Szczesny B, Boorgula MP, Taub MA, Kenny E, Mathias RA, Barnes KC, CAAPA., Khurana Hershey GK, Kercsmar CM, Gereige JD, Makhija M, Gruchalla RS, Gill MA, Liu AH, Rastogi D, Busse W, Gergen PJ, Visness CM, Gold DR, Hartert T, Johnson CC, Lemanske RF Jr, Martinez FD, Miller RL, Ownby D, Seroogy CM, Wright AL, Zoratti EM, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Nobrega MA, Altman MC, Jackson DJ, Gern JE, McKennan CG, Ober C -
Sep 2022
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
EBioMedicineOzonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, IMPACC study group members. -
Aug 2022
Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial.
LancetJackson DJ, Bacharier LB, Gergen PJ, Gagalis L, Calatroni A, Wellford S, Gill MA, Stokes J, Liu AH, Gruchalla RS, Cohen RT, Makhija M, Khurana Hershey GK, O'Connor GT, Pongracic JA, Sherenian MG, Rivera-Spoljaric K, Zoratti EM, Teach SJ, Kattan M, Dutmer CM, Kim H, Lamm C, Sheehan WJ, Segnitz RM, Dill-McFarland KA, Visness CM, Becker PM, Gern JE, Sorkness CA, Busse WW, Altman MC, US National Institute of Allergy and Infectious Disease's Inner City Asthma Consortium. -
Jun 2022
DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Proc Natl Acad Sci U S AMagnaye KM, Clay SM, Nicodemus-Johnson J, Naughton KA, Huffman J, Altman MC, Jackson DJ, Gern JE, Hogarth DK, Naureckas ET, White SR, Ober C -
May 2022
Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Genome MedClay SM, Schoettler N, Goldstein AM, Carbonetto P, Dapas M, Altman MC, Rosasco MG, Gern JE, Jackson DJ, Im HK, Stephens M, Nicolae DL, Ober C -
Apr 2022
Eosinophil-mediated suppression and Anti-IL-5 enhancement of plasmacytoid dendritic cell interferon responses in asthma.
J Allergy Clin ImmunolDill-McFarland KA, Schwartz JT, Zhao H, Shao B, Fulkerson PC, Altman MC, Gill MA -
Apr 2022
17q12-q21 variants interact with early-life exposures to modify asthma risk in Black children.
Clin Exp AllergyGereige JD, Morin A, Calatroni A, Visness CM, Wood RA, Kattan M, Bacharier LB, Becker P, Altman MC, Gern JE, Ober C, O'Connor GT -
Feb 2022
Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations.
J Allergy Clin ImmunolMcCauley KE, Flynn K, Calatroni A, DiMassa V, LaMere B, Fadrosh DW, Lynch KV, Gill MA, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Liu AH, Johnson CC, Kim H, Kattan M, O'Connor GT, Bacharier LB, Teach SJ, Gergen PJ, Wheatley LM, Togias A, LeBeau P, Presnell S, Boushey HA, Busse WW, Gern JE, Jackson DJ, Altman MC, Lynch SV, National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium. -
Jan 2022
Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma.
Eur Respir JAl-Shaikhly T, Murphy RC, Parker A, Lai Y, Altman MC, Larmore M, Altemeier WA, Frevert CW, Debley JS, Piliponsky AM, Ziegler SF, Peters MC, Hallstrand TS