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Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes.
Sci Transl MedSmithmyer ME, Hu A, Dufort MJ, Hocking AM, Wiedeman AE, Fasano KJ, Torgerson TR, Skene PJ, Reading J, Li X, Gong Q, Long SA, Lacy-Hulbert A, Gustafson CE, Buckner JH, Speake C, members of the BRI Sound Life Project Team, BRI Sound Life Project Team -
Defining a novel DYRK1A-gp130/IL-6R-pSTAT axis that regulates Th17 differentiation.
ImmunohorizonsMalueg M, Moo KG, Arnett A, Edwards TH, Ruskin SL, Lambert K, Subramanyam A, Dufort MJ, Gersuk VH, Partridge R, Buckner JH, Khor B -
Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.
ImmunityOgishi M, Kitaoka K, Good-Jacobson KL, Rinchai D, Zhang B, Wang J, Gies V, Rao G, Nguyen T, Avery DT, Khan T, Smithmyer ME, Mackie J, Yang R, Arias AA, Asano T, Ponsin K, Chaldebas M, Zhang P, Peel JN, Bohlen J, Lévy R, Pelham SJ, Lei WT, Han JE, Fagniez I, Chrabieh M, Laine C, Langlais D, Gruber C, Al Ali F, Rahman M, Aytekin C, Benson B, Dufort MJ, Domingo-Vila C, Moriya K, Shlomchik M, Uzel G, Gray PE, Suan D, Preece K, Chua I, Okada S, Chikuma S, Kiyonari H, Tree TI, Bogunovic D, Gros P, Marr N, Speake C, Oram RA, Béziat V, Bustamante J, Abel L, Boisson B, Korganow AS, Ma CS, Johnson MB, Chamoto K, Boisson-Dupuis S, Honjo T, Casanova JL, Tangye SG -
Hypoxia-inducible factor 2α promotes protective Th2 cell responses during intestinal helminth infection.
J ImmunolLabuda JC, Olsen TM, Verma S, Kimmel S, Edwards TH, Dufort MJ, Harrison OJ -
An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy.
Cell RepJamison BL, Lawrance M, Wang CJ, DeBerg HA, Ziegler LJ, Sansom DM, Gavin MA, Walker LSK, Campbell DJ -
T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts.
bioRxivDeBerg HA, Fahning ML, Varkhande SR, Schlenker JD, Schmitt WP, Gupta A, Singh A, Gratz IK, Carlin JS, Campbell DJ, Morawski PA -
Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes.
Sci Transl MedWaterman HR, Dufort MJ, Posso SE, Ni M, Li LZ, Zhu C, Raj P, Smith KD, Buckner JH, Hamerman JA -
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers.
ImmunityVerma S, Dufort MJ, Olsen TM, Kimmel S, Labuda JC, Scharffenberger S, McGuire AT, Harrison OJ -
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
J Exp MedJohnson MB, Ogishi M, Domingo-Vila C, de Franco E, Wakeling MN, Imane Z, Resnick B, Williams E, Galão RP, Caswell R, Russ-Silsby J, Seeleuthner Y, Rinchai D, Fagniez I, Benson B, Dufort MJ, Speake C, Smithmyer ME, Hudson M, Dobbs R, EXE-T1D consortium, Quandt Z, Hattersley AT, Zhang P, Boisson-Dupuis S, Anderson MS, Casanova JL, Tree TI, Oram RA -
Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy.
AllergyVoskamp AL, Khosa S, Phan T, DeBerg HA, Bingham J, Hew M, Smith W, Abramovitch J, Rolland JM, Moyle M, Nadeau KC, Lack G, Larché M, Wambre E, O'Hehir RE, Hickey P, Prickett SR -
An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cells.
bioRxivJamison BL, Lawrance M, Wang CJ, DeBerg HA, Sansom DM, Gavin MA, Walker LSK, Campbell DJ -
Safety and immunopharmacology of ASP0892 in adults or adolescents with peanut allergy: two randomized trials.
AllergyFerslew BC, Smulders R, Zhu T, Blauwet MB, Kusawake T, Spence A, Aldridge K, DeBerg HA, Khosa S, Wambre E, Chichili GR -
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes.
JCI InsightBalmas E, Chen J, Hu AK, DeBerg HA, Rosasco MG, Gersuk VH, Serti E, Speake C, Greenbaum CJ, Nepom GT, Linsley PS, Cerosaletti K -
IL-6-targeted therapies directed to cytokine or receptor blockade drive distinct alterations in T cell function.
JCI InsightSpeake C, Habib T, Lambert K, Hundhausen C, Lord S, Dufort MJ, Skinner SO, Hu A, Kinsman M, Jones BE, Maerz MD, Tatum M, Hocking AM, Nepom GT, Greenbaum CJ, Buckner JH -
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells.
Nat GenetMouri K, Guo MH, de Boer CG, Lissner MM, Harten IA, Newby GA, DeBerg HA, Platt WF, Gentili M, Liu DR, Campbell DJ, Hacohen N, Tewhey R, Ray JP
