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Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.
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Changing the Course of Disease in Type 1 Diabetes
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The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes.
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Non-Genetically Encoded Epitopes Are Relevant Targets in Autoimmune Diabetes.
BiomedicinesNguyen H, Guyer P, Ettinger RA, James EA -
Circulating TFH cells as a marker for early therapeutic intervention in T1D.
Nature ImmunologyBettelli E, Campbell DJ -
Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes.
Science AdvancesChow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum CJ, Nepom GT, Kwok WW -
Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes.
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Treg gene signatures predict and measure type 1 diabetes trajectory.
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Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.
DiabetesMarré ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA -
Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft.
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Emerging Concepts on Disease-Modifying Therapies in Type 1 Diabetes.
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Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.
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Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home.
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Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes.
Diabetic MedicineRedondo MJ, Grant SF, Davis A, Greenbaum CJ, T1D Exchange Biobank. -
The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice.
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