Cardiology Clinical Research

Clinical Trials

Cardiology

Benaroya Research Institute and Virginia Mason Medical Center conduct clinical trials to discover new treatments and approaches to cardiovascular disease. Research studies are conducted for a variety of heart diseases including heart valve disease, coronary artery disease, hypertrophic cardiomyopathy, and atrial fibrillation.

Clinical Research Studies in Cardiology

We have ongoing clinical research studies in multiple areas of cardiovascular disease. Studies labeled as “Enrolling” are actively accepting new participants, while studies labeled as “Closed to Enrollment” are still active but no longer seeking new participants.

Please email Cardiology Clinical Research or call (206) 287-6260 for more information.

A Phase 3, Multi-Center, Randomized, Double-Blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults with Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy

Learn more at Clinicaltrials.gov

Principal Investigator: Mariko Harper, MD
Status: Enrolling

A Randomized, Sham-Controlled, Clinical Trial for Evaluation of the Edwards APTURE Transcatheter Shunt System (ALT-FLOW II)

Learn more at Clinicaltrials.gov

Principal Investigator: Bhanu Gupta, MD
Status: Enrolling

An Open Label Study to Evaluate the Safety, Tolerability, PHarmacokinetic, and Pharmacodynamic Effects of EDG-7500 in Adults with Obstructive Hypertrophic Cardiomyopathy

Learn more at Clinicaltrials.gov

Principal Investigator: Mariko Harper, MD
Status: Enrolling

Deliver Insights in Hypertrophic Cardiomyopathy and Observational Outcomes in Real World (DISCOVER-HCM): United States Prospective Registry Study

Learn more at Clinicaltrials.gov

Principal Investigator: Mariko Harper, MD
Status: Enrolling

HERMES: Effects of ziltivekimab versus placebo on morbidity and mortality in patients with heart failure with mildly reduced or preserved ejection fraction and systemic inflammation

Learn more at Clinicaltrials.gov

Principal Investigator: Sara Weiss, MD
Status: Enrolling

Irrigated Radio Frequency Ablation to Terminate Non-Paroxysmal Atrial Fibrillation (Terminate AF Study)

Learn more at Clinicaltrials.gov

Principal Investigator: Robert Moraca, MD
Status: Enrolling

Percutaneous or Surgical Mitral Valve REpair in PAtients with Primary Mitral Regurgitation whose mitral valve has been determined to be suitable for correction by MV repair surgery.

Learn more at Clinicaltrials.gov

Principal Investigator: Ming Zhang, MD
Status: Enrolling

Post-Approval Study Protocol for Hybrid Convergent of Epicardial RF Ablation and Endocardial Ablation for the Treatment of Symptomatic Long Standing Persistent AF.

Learn more at Clinicaltrials.gov

Principal Investigator: Robert Moraca, MD
Status: Enrolling

A randomized, double-blind, placebo-controlled, multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease (Victorion-2 PREVENT)

Learn more at Clinicaltrials.gov

Principal Investigator: Drew Baldwin, MD
Status: Closed to Enrollment

Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP II TR)A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCA

A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCAL Transcatheter Valve Repair System and optimal medical therapy (OMT) compared to OMT alone in patients with tricuspid regurgitation.

Learn more at Clinicaltrials.gov

Principal Investigator: Ming Zhang, MD
Status: Closed to Enrollment

Edwards Transcatheter Valve Tricuspid Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy using a Novel Device.

Learn more at Clinicaltrials.gov

Principal Investigator: Ming Zhang, MD
Status: Closed to Enrollment