Cardiology
Benaroya Research Institute and Virginia Mason Medical Center conduct clinical trials to discover new treatments and approaches to cardiovascular disease. Research studies are conducted for a variety of heart diseases including heart valve disease, coronary artery disease, hypertrophic cardiomyopathy, and atrial fibrillation.
Clinical Research Studies in Cardiology
We have ongoing clinical research studies in multiple areas of cardiovascular disease. Studies labeled as “Enrolling” are actively accepting new participants, while studies labeled as “Closed to Enrollment” are still active but no longer seeking new participants.
Please email Cardiology Clinical Research or call (206) 287-6260 for more information.
- A Randomized, Sham-Controlled, Clinical Trial for Evaluation of the Edwards APTURE Transcatheter Shunt System (ALT-FLOW II)
Learn more at Clinicaltrials.gov
Principal Investigator: Bhanu Gupta, MD
Status: Enrolling- An Open Label Study to Evaluate the Safety, Tolerability, PHarmacokinetic, and Pharmacodynamic Effects of EDG-7500 in Adults with Obstructive Hypertrophic Cardiomyopathy
Learn more at Clinicaltrials.gov
Principal Investigator: Mariko Harper, MD
Status: Enrolling- DELIVER INSIGHTS IN HYPERTROPHIC CARDIOMYOPATHY AND OBSERVATIONAL OUTCOMES IN REAL WORLD (DISCOVER-HCM): UNITED STATES PROSPECTIVE REGISTRY STUDY
Learn more at Clinicaltrials.gov
Principal Investigator: Mariko Harper, MD
Status: Enrolling- Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP II TR)A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCA
A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCAL Transcatheter Valve Repair System and optimal medical therapy (OMT) compared to OMT alone in patients with tricuspid regurgitation.
Learn more at Clinicaltrials.gov
Principal Investigator: Ming Zhang, MD
Status: Enrolling- HERMES: Effects of ziltivekimab versus placebo on morbidity and mortality in patients with heart failure with mildly reduced or preserved ejection fraction and systemic inflammation
Learn more at Clinicaltrials.gov
Principal Investigator: Sara Weiss, MD
Status: Enrolling- Irrigated Radio Frequency Ablation to Terminate Non-Paroxysmal Atrial Fibrillation (Terminate AF Study)
Learn more at Clinicaltrials.gov
Principal Investigator: Robert Moraca, MD
Status: Enrolling- Percutaneous or Surgical Mitral Valve REpair in PAtients with Primary Mitral Regurgitation whose mitral valve has been determined to be suitable for correction by MV repair surgery.
Learn more at Clinicaltrials.gov
Principal Investigator: Ming Zhang, MD
Status: Enrolling- Post-Approval Study Protocol for Hybrid Convergent of Epicardial RF Ablation and Endocardial Ablation for the Treatment of Symptomatic Long Standing Persistent AF.
Learn more at Clinicaltrials.gov
Principal Investigator: Robert Moraca, MD
Status: Enrolling- A randomized, double-blind, placebo-controlled, multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease (Victorion-2 PREVENT)
Learn more at Clinicaltrials.gov
Principal Investigator: Drew Baldwin, MD
Status: Closed to Enrollment
- Edwards Transcatheter Valve Tricuspid Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy using a Novel Device.
Learn more at Clinicaltrials.gov
Principal Investigator: Ming Zhang, MD
Status: Closed to Enrollment