Faculty & Scientific Staff
Edward Irvine, PhD
Edward Irvine received his BS in biology from Stanford University in 2016 and his PhD in biological sciences in public health from Harvard University in 2022. He conducted his doctoral research in the laboratories of Galit Alter, PhD, and Sarah Fortune, MD, studying antibody responses to Mycobacterium tuberculosis infection and vaccination. He then completed his postdoctoral research in the laboratory of Sai Reddy, PhD, at ETH Zürich, where he developed machine learning-guided platforms to map, predict and design protein function. Dr. Irvine joined the faculty of Benaroya Research Institute as an Assistant Member in 2026. His research focuses on understanding how antibodies and other proteins communicate with immune cells and developing new ways to engineer these interactions to improve human health.
Featured Publications
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Generative Design of Antibody Fc-variants with Synthetic and Programmable Functional Profiles
bioRxivIrvine EB, Bikias T, Stampkopoulos E, Frei L, Schürmann N, Warrender AK, Schmid H, Coukos D, Yang H, Minot M, Kelton W, Reddy ST -
High-dose Intravenous BCG Vaccination Induces Enhanced Immune Signaling in the Airways
Sci AdvPeters JM, Irvine EB, Makatsa MS, Rosenberg JM, Wadsworth MH 2nd, Hughes TK, Sutton MS, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Seshadri C, Flynn JL, Shalek AK, Fortune SM, Bryson BD -
Advancing Antibody Engineering through Synthetic Evolution and Machine Learning
J ImmunolIrvine EB, Reddy ST -
Fc-Engineered Antibodies Promote Neutrophil-Dependent Control of Mycobacterium Tuberculosis
Nat MicrobiolIrvine EB, Nikolov A, Khan MZ, Peters JM, Lu R, Sixsmith J, Wallace A, van Woudenbergh E, Shin S, Karpinski W, Hsiao JC, Casadevall A, Bryson BD, Cavacini L, Grace PS, Alter G, Fortune SM -
Robust IgM Responses Following Intravenous Vaccination with Bacille Calmette-Guérin Associate with Prevention of Mycobacterium Tuberculosis Infection in Macaques
Nat ImmunolIrvine EB, O'Neil A, Darrah PA, Shin S, Choudhary A, Li W, Honnen W, Mehra S, Kaushal D, Gideon HP, Flynn JL, Roederer M, Seder RA, Pinter A, Fortune S, Alter G