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Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.
J Clin InvestMuraro PA, Vergelli M, Kalbus M, Banks DE, Nagle JW, Tranquill LR, Nepom GT, Biddison WE, McFarland HF, Martin R -
Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis.
Arthritis RheumPenzotti JE, Nepom GT, Lybrand TP -
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.
J Clin InvestHershberg RM, Framson PE, Cho DH, Lee LY, Kovats S, Beitz J, Blum JS, Nepom GT -
alphaT244M mutation affects the redox, kinetic, and in vitro folding properties of Paracoccus denitrificans electron transfer flavoprotein
BiochemistryGriffin KJ, Dwyer TM, Manning MC, Meyer JD, Carpenter JF, Frerman FE -
Recognition of contiguous allele-specific peptide elements in the rubella virus E1 envelope protein.
VaccineNepom GT, Domeier ME, Ou D, Kovats S, Mitchell LA, Tingle AJ -
MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments.
Tissue AntigensGaur LK, Nepom GT, Snyder KE, Anderson J, Pandarpurkar M, Yadock W, Heise ER -
Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201.
Hum ImmunolKoelle DM, Johnson ML, Ekstrom AN, Byers P, Kwok WW -
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
J Clin InvestWicker LS, Chen SL, Nepom GT, Elliott JF, Freed DC, Bansal A, Zheng S, Herman A, Lernmark A, Zaller DM, Peterson LB, Rothbard JB, Cummings R, Whiteley PJ -
CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles.
J ImmunolChapman A, Stewart SJ, Nepom GT, Green WF, Crowe D, Thomas JW, Miller GG -
Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.
J ImmunolBuckner JH, Kwok WW, Nepom BS, Nepom GT -
Characterization of the HLA-restrictive elements of a rubella virus-specific cytotoxic T cell clone: influence of HLA-DR4 beta chain residue 74 polymorphism on antigenic peptide-T cell interaction.
Int ImmunolOu D, Mitchell LA, Domeier ME, Tsang AO, Décarie D, Tingle AJ, Nepom GT, Lacroix M, Zrein M -
Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules.
Proc Natl Acad Sci U S ANepom BS, Nepom GT, Coleman M, Kwok WW -
Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms.
Proc Natl Acad Sci U S AGaur LK, Nepom GT -
Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions.
Eur J ImmunolNepom GT, Ou D, Lybrand TP, DeWeese C, Domeier ME, Buckner JH, Mitchell LA, Tingle AJ -
A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis.
J AutoimmunPenzotti JE, Doherty D, Lybrand TP, Nepom GT
