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T cell selection and differential activation on structurally related HLA-DR4 ligands.
J ImmunolGebe JA, Novak EJ, Kwok WW, Farr AG, Nepom GT, Buckner JH -
Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1(1/2) diabetes in patients presenting with type 2 diabetes.
MetabolismJuneja R, Hirsch IB, Naik RG, Brooks-Worrell BM, Greenbaum CJ, Palmer JP -
Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset.
Int ImmunolNovak EJ, Masewicz SA, Liu AW, Lernmark A, Kwok WW, Nepom GT -
Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens.
J ImmunolNovak EJ, Liu AW, Gebe JA, Falk BA, Nepom GT, Koelle DM, Kwok WW -
The role of the DR4 shared epitope in selection and commitment of autoreactive T cells in rheumatoid arthritis.
Rheum Dis Clin North AmNepom GT -
Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes.
J ImmunolBrooks-Worrell B, Gersuk VH, Greenbaum CJ, Palmer JP -
CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells.
J ImmunolKoelle DM, Chen HB, Gavin MA, Wald A, Kwok WW, Corey L -
Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).
Proc Natl Acad Sci U S ANepom GT, Lippolis JD, White FM, Masewicz S, Marto JA, Herman A, Luckey CJ, Falk B, Shabanowitz J, Hunt DF, Engelhard VH, Nepom BS -
Type I diabetes manifested solely by 2-h oral glucose tolerance test criteria.
DiabetesGreenbaum CJ, Cuthbertson D, Krischer JP, Disease Prevention Trial of Type I Diabetes Study Group. -
Low-dose streptozotocin induces sustained hyperglycemia in Macaca nemestrina.
AutoimmunityGaur LK, Nepom GT, Lernmark A -
Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65.
AutoimmunityMasewicz SA, Meldrum N, Gersuk V, Gaur L, Hagopian W, Moriarity L, Nepom GT -
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Nat GenetBrunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F -
School-age children born to diabetic mothers and to mothers with gestational diabetes exhibit a high rate of inattention and fine and gross motor impairment.
J Pediatr Endocrinol MetabOrnoy A, Ratzon N, Greenbaum C, Wolf A, Dulitzky M -
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin.
J Clin InvestAlleva DG, Crowe PD, Jin L, Kwok WW, Ling N, Gottschalk M, Conlon PJ, Gottlieb PA, Putnam AL, Gaur A -
Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response.
J ImmunolReichstetter S, Ettinger RA, Liu AW, Gebe JA, Nepom GT, Kwok WW
