Study of Foxp3ΔExon2-expressing regulatory T cells in humans and mice

We generated mice that express an autoimmune-driving isoform of the Foxp3 gene without the second coding exon of the gene (called Foxp3 ΔExon2 mice).

Foxp3ΔExon2-expressing mice have higher titers of IgE that target skin autoantigens. In this study, we are investigating whether these IgE autoantibodies mediate photosensitivity reactions after exposure to low-dose Ultraviolet B light.