Across multiple tissues, conserved anatomical sites termed adventitial cuffs have been shown to be focal points within tissues for the maintenance of tissue homeostasis and initiation of inflammatory cascades.
Although thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33) are best known as alarmin cytokines produced by barrier epithelium, specific populations of adventitial fibroblasts have now also been shown to be important sources of TLSP and IL-33.
We are using in vivo models as well as transcriptomic and epigenomic approaches to understand how TLSP and IL-33 signaling at adventitial sites in the lungs and skin maintain tissue immune homeostasis and regulate type 2 inflammation and tissue repair.
Additional Research Projects
Discover more research projects from the
Ziegler Lab.
Regulation of Humoral Immunity by Thymic Stromal Lymphopoietin
Cell-intrinic regulation of germinal centers by Thymic Stromal Lymphopoetin Receptor (TSLPR) signaling
Study of Foxp3ΔExon2-expressing regulatory T cells in humans and mice
Characterization of IgE-mediated photosensitivity in Foxp3ΔExon2-expressing mice
The Role of TSLPR+St2+ Tregs in colorectal cancer
Diagnosis and therapy for colorectal cancer targeting a novel subset of Tregs.
