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Phase I Clinical Trial of Islet Antigen-Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes
DiabetesCarla Greenbaum, S Alice Long, Stephen E Gitelman, Jason L Gaglia, Mark Daniels, Todd M Brusko, Sandra Lord, Brian N Bundy, Jeffrey P Krischer, Michael J Haller, Andrea K Steck, Linda A DiMeglio, Carmella Evans-Molina, Antoinette Moran, Priya Prahalad, Darrell M Wilson, William E Russell, Jennifer L Sherr, Philip Raskin, Mark A Clements, Wayne V Moore, Ingrid Libman, Karsten Wassermann, Matthias von Herrath, Regine Bergholdt, Hanne Hastrup, Sarah E Kobernat, Anna M Kus, Lin Wei Tung, Robin S Goland, Kevan C Herold, Type 1 Diabetes TrialNet Study Group -
Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes
J Clin InvestGabriele Sassi, Pierre Lemaitre, Laia Fernández Calvo, Francesca Lodi, Álvaro Cortés Calabuig, Samal Bissenova, Amber Wouters, Laure Degroote, Marijke Viaene, Niels Vandamme, Lauren Higdon, Peter S Linsley, S Alice Long, Chantal Mathieu, Conny Gysemans -
Transcriptional fingerprinting of regulatory T cells: ensuring quality in cell therapy applications.
Front ImmunolCheng Z, Wang LJ, Honaker Y, Cincotta SA, Page CE, Vollhardt S, Yuan V, Long SA, Xiao Y, Beilke JN, Arron JR, Bluestone JA -
Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes.
Sci Transl MedSmithmyer ME, Hu A, Dufort MJ, Hocking AM, Wiedeman AE, Fasano KJ, Torgerson TR, Skene PJ, Reading J, Li X, Gong Q, Long SA, Lacy-Hulbert A, Gustafson CE, Buckner JH, Speake C, members of the BRI Sound Life Project Team, BRI Sound Life Project Team -
Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes
Nat CommunAna Lledó-Delgado, Paula Preston-Hurlburt, Lauren Higdon, Alex Hu, Eddie James, Noha Lim, S Alice Long, James McNamara, Hai Nguyen, Elisavet Serti, Tomokazu S Sumida, Kevan C Herold -
Emerging Concepts and Success Stories in Type 1 Diabetes Research: A Road Map for a Bright Future.
DiabetesMallone R, Sims E, Achenbach P, Mathieu C, Pugliese A, Atkinson M, Dutta S, Evans-Molina C, Klatzmann D, Koralova A, Long SA, Overbergh L, Rodriguez-Calvo T, Ziegler AG, You S -
42-parameter mass cytometry panel to assess cellular and functional phenotypes of leukocytes in bronchoalveolar lavage of Rhesus macaque.
bioRxivMakatsa MS, Kus A, Wiedeman A, Long SA, Seshadri C -
Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at-risk for type 1 diabetes.
J Clin InvestLledó-Delgado A, Preston-Hurlburt P, Currie S, Clark P, Linsley PS, Long SA, Liu C, Koroleva G, Martins AJ, Tsang JS, Herold KC -
PD-L1 and PD-1 Are Associated with Clinical Outcomes and Alveolar Immune Cell Activation in ARDS.
Am J Respir Cell Mol BiolMorrell ED, Holton SE, Wiedeman A, Kosamo S, Mitchem MA, Dmyterko V, Franklin Z, Garay A, Stanaway IB, Liu T, Sathe NA, Mabrey FL, Stapleton RD, Malhotra U, Speake C, Hamerman JA, Pipavath S, Evans L, Bhatraju PK, Long SA, Wurfel MM, Mikacenic C -
Interconnected lineage trajectories link conventional and natural killer (NK)-like exhausted CD8(+) T cells beneficial in type 1 diabetes.
Commun BiolWitkop EM, Diggins K, Wiedeman A, Serti E, Nepom G, Gersuk VH, Fuchs B, Long SA, Linsley PS -
Integrating Omics into Functional Biomarkers of Type 1 Diabetes.
Cold Spring Harb Perspect MedLong SA, Linsley PS -
A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes.
Sci Transl MedBender C, Wiedeman AE, Hu A, Ylescupidez A, Sietsema WK, Herold KC, Griffin KJ, Gitelman SE, Long SA, T-Rex Study Group†, T-Rex Clinical Study Group -
Impact on in-depth immunophenotyping of delay to peripheral blood processing.
Clin Exp ImmunolHigdon LE, Scheiding S, Kus AM, Lim N, Long SA, Anderson MS, Wiedeman AE -
Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles.
Front ImmunolLong SA, Muir VS, Jones BE, Wall VZ, Ylescupidez A, Hocking AM, Pribitzer S, Thorpe J, Fuchs B, Wiedeman AE, Tatum M, Lambert K, Uchtenhagen H, Speake C, Ng B, Heubeck AT, Torgerson TR, Savage AK, Maldonado MA, Ray N, Khaychuk V, Liu J, Linsley PS, Buckner JH -
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review.
Commun Med (Lond)Felton JL, Redondo MJ, Oram RA, Speake C, Long SA, Onengut-Gumuscu S, Rich SS, Monaco GSF, Harris-Kawano A, Perez D, Saeed Z, Hoag B, Jain R, Evans-Molina C, DiMeglio LA, Ismail HM, Dabelea D, Johnson RK, Urazbayeva M, Wentworth JM, Griffin KJ, Sims EK, ADA/EASD PMDI
