Unified Framework for Autoimmune Disease Development

We propose that there is a common framework that can be applied to the development of autoimmunity, which includes three phases:

  1. Biological activity (no symptoms)
  2. Evidence of target organ involvement (non-specific symptoms)
  3. Clinical/Symptomatic Disease (meets officially recognized diagnostic/classification criteria)

It is our goal to be able to identify markers of and treatments that can be applied during phase B of autoimmunity progression to prevent or delay the development of clinical disease.

Project Team Members can access the project here