Impact of IL-2/IL-2R signaling in T1D

The IL-2/IL-2R signaling pathway is associated with T1D and other autoimmune diseases, impacting Treg but also many other cell types. We discovered reduced IL-2R signaling in effector CD4 T cells of T1D subjects that is partially explained by autoimmune-associated genetic risk alleles. How reduced IL-2R signaling in effector T cell contributes to T1D pathology is not well understood.  We are exploring molecular mechanisms of reduced IL-2 signaling, and modultion of IL-2R signaling in disease progression and with therapy.