Dedicator of cytokinesis 8 (DOCK8) is a guanine nucleotide exchange factor expressed in hematopoietic cells. DOCK8 deficiency is characterized by allergic inflammation and susceptibility towards infections, autoimmunity, and malignancy.
The Bettelli Lab has been studying the mechanisms by which DOCK8 modulates the function of adaptive and innate cells and further contributes to the progression of autoimmunity.
Additional Research Projects
Discover more research projects from the
Bettelli Lab.
Mechanisms of T Cell Differentiation and Pathogenicity
T cells differentiate in different subsets of effector T helper (Th) cells and have specialized effector functions.
Mechanisms of T Cell Regulation
The Bettelli Lab has discovered that Th cells producing IFN-g, IL-17 and GM-CSF are differentially regulated by Tregs during the course of central nervous system (CNS) autoimmunity.
Modulation of the Immune Response by STAT1
Using loss and gain of function models, the Bettelli Lab is currently investigating how STAT1-mediated signaling modulates the function of different immune cells and participates in the pathogenesis of different autoimmune diseases.
