Available Technology

Variable Lymphocyte Receptors – Lamprey

Tech Summary

The researchers at Benaroya Research Institute and University of Alabama at Birmingham have identified and isolated a panel of highly variable lymphocyte receptors in Lamprey, Petromyzon marinus. The panel is derived from functional receptors involved in adaptive immune response within Lamprey. These receptors are generated through somatic rearrangement resulting in diverse set of receptors, each with unique antigen specificities. These receptors are able to selectively bind various virus, bacterium, parasite, fungus, and toxins.

Detailed Description

Petromyzon marinus, commonly known as sea lamprey, is a jawless vertebrate. It is the first non-jawed vertebrate identified to have an adaptive immune system with variable immune receptors analogous to T-lymphocyte receptors found in jawed vertebrates.

Stages of Development

DNA sequences and corresponding amino acid sequences for a panel of variable lymphocyte receptors of lamprey are available.

IP Position

The University of Alabama at Birmingham and Benaroya Research Institute has issued patents in the United States and Australia, and pending patent applications in several jurisdictions worldwide.

Featured Publications

Mar 2025

A molecular basis for milk allergen immune recognition in eosinophilic esophagitis.

J Allergy Clin Immunol

Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA

Mar 2025

A coding single nucleotide polymorphism in the interleukin-6 receptor enhances IL-6 signalling in CD4 T cells and predicts treatment response to tocilizumab in giant cell arteritis.

Ann Rheum Dis

Zorc R, Redmond C, Sylvester M, Maclean M, Yamamoto de Almeida L, Quinn KA, Tomelleri A, Campochiaro C, Dagna L, Gutierrez-Rodrigues F, Wells KV, Rankin C, Hait SH, Palmer C, Corty R, Bick A, Lambert K, Buckner JH, O'Shea JJ, Park JK, Gadina M, Grayson PC

Mar 2025

A systematic review of machine learning-based prognostic models for acute pancreatitis: Towards improving methods and reporting quality.

PLoS Med

Critelli B, Hassan A, Lahooti I, Noh L, Park JS, Tong K, Lahooti A, Matzko N, Adams JN, Liss L, Quion J, Restrepo D, Nikahd M, Culp S, Lacy-Hulbert A, Speake C, Buxbaum J, Bischof J, Yazici C, Evans-Phillips A, Terp S, Weissman A, Conwell D, Hart P, Ramsey M, Krishna S, Han S, Park E, Shah R, Akshintala V, Windsor JA, Mull NK, Papachristou G, Celi LA, Lee P

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Considerations for more actionable consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Reply to Mallone R [letter].

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Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Dutta S, Ebekozien O, Elding Larsson H, Frohnert BI, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendriks E, Holt RIG, Ismail HM, Jacobsen LM, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark A, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Oron T, Patil SP, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Speake C, Steck AK, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA

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Defining a novel DYRK1A-gp130/IL-6R-pSTAT axis that regulates Th17 differentiation.

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Malueg M, Moo KG, Arnett A, Edwards TH, Ruskin SL, Lambert K, Subramanyam A, Dufort MJ, Gersuk VH, Partridge R, Buckner JH, Khor B

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