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A Proteome-wide Atlas of Humoral Immunity to Mycobacterium Tuberculosis Across the Spectrum of Disease
Front ImmunolKhan MZ, Irvine EB, Cizmeci D, Davies LRL, Randall AZ, Pablo J, Vidal SJ, Lasrado N, Darrah PA, Hsiao JC, Mann C, Nair S, Grace PS, Fontana L, Juelg B, Barouch DH, Restrepo BI, Roederer M, Seder RA, Wallis RS, Churchyard G, Stein CM, Boom WH, Campo JJ, Alter G -
Generative Design of Antibody Fc-variants with Synthetic and Programmable Functional Profiles
bioRxivIrvine EB, Bikias T, Stamkopoulos E, Frei L, Schürmann N, Warrender AK, Schmid H, Coukos D, Yang H, Minot M, Kelton W, Reddy ST -
High-throughput Cell-free Profiling of SARS-CoV-2 RBD Variants Enables Rapid and Quantitative In Vitro Affinity Landscape Mapping
bioRxivGrasemann L, Han J, Tischler J, Arefi F, Gonzalez Castillo MA, Irvine EB, Chen N, Reddy ST, Maerkl SJ -
Simple High-throughput Encoding of Deep Mutational Scanning Libraries by Oligo-based Golden Gate Assembly
bioRxivHanning KR, Walker EJ, Beijerling K, Irvine EB, Steel JJ, Kelton W -
Antibody-Fab and -Fc Features Promote Mycobacterium Tuberculosis Restriction
ImmunityGrace PS, Peters JM, Sixsmith J, Lu R, Irvine EB, Luedeman C, Fenderson BA, Vickers A, Slein MD, McKitrick T, Wei MH, Cummings RD, Wallace A, Cavacini LA, Choudhary A, Proulx MK, Sundling C, Källenius G, Reljic R, Ernst JD, Casadevall A, Locht C, Pinter A, Sassetti CM, Bryson BD, Fortune SM, Alter G -
Deep Mutational Learning for the Selection of Therapeutic Antibodies Resistant to the Evolution of Omicron Variants of SARS-CoV-2
Nat Biomed EngFrei L, Gao B, Han J, Taft JM, Irvine EB, Weber CR, Kumar RK, Eisinger BN, Ignatov A, Yang Z, Reddy ST -
High-dose Intravenous BCG Vaccination Induces Enhanced Immune Signaling in the Airways
Sci AdvPeters JM, Irvine EB, Makatsa MS, Rosenberg JM, Wadsworth MH 2nd, Hughes TK, Sutton MS, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Seshadri C, Flynn JL, Shalek AK, Fortune SM, Bryson BD -
Markov Field Network Model of Multi-modal Data Predicts Effects of Immune System Perturbations on Intravenous BCG Vaccination in Macaques
Cell SystWang S, Myers AJ, Irvine EB, Wang C, Maiello P, Rodgers MA, Tomko J, Kracinovsky K, Borish HJ, Chao MC, Mugahid D, Darrah PA, Seder RA, Roederer M, Scanga CA, Lin PL, Alter G, Fortune SM, Flynn JL, Lauffenburger DA -
Are Glycans Really Non-templated? Deploying AI Deciphers how the Underlying Protein Helps Shape their Glycans
GlycobiologyKellman BP, Sandoval D, Zaytseva OO, Brock K, Baboo S, Nachmanson D, Irvine EB, Armingol E, Mih N, Zhang Y, Jeffris M, Bartels P, Nguyen T, Tam A, Gasman S, Ilan S, Shamie I, Diedrich JK, Wang X, van Woudenbergh E, Altman M, Aylward A, Bao B, Castro A, Sorrentino J, Chiang A, Campbell M, Bartsch Y, Aguilar-Calvo P, Sigurdson C, Alter G, Lauc G, Yates III JR, Marks D, Lisacek F, Mariethoz J, Shaul S, Alteri M, Bojar D, Lewis NE -
Fc-Engineered Antibodies Promote Neutrophil-Dependent Control of Mycobacterium Tuberculosis
Nat MicrobiolIrvine EB, Nikolov A, Khan MZ, Peters JM, Lu R, Sixsmith J, Wallace A, van Woudenbergh E, Shin S, Karpinski W, Hsiao JC, Casadevall A, Bryson BD, Cavacini L, Grace PS, Alter G, Fortune SM -
Distinctive Antibody Responses to Mycobacterium Tuberculosis in Pulmonary and Brain Infection
BrainSpatola M, Nziza N, Irvine EB, Cizmeci D, Jung W, Van LH, Nhat LTH, Ha VTN, Phu NH, Ho DTN, Thwaites GE, Lauffenburger DA, Fortune S, Thuong NTT, Alter G -
Fc-engineered Antibodies Leverage Neutrophils to Drive Control of Mycobacterium Tuberculosis
Nat MicrobiolIrvine EB, Nikolov A, Khan MZ, Peters JM, Lu R, Sixsmith J, Wallace A, van Woudenbergh E, Shin S, Karpinski W, Hsiao JC, Casadevall A, Bryson BD, Cavacini L, Grace PS, Alter G, Fortune SM -
Protein Structure, a Genetic Encoding for Glycosylation
bioRxivKellman BP, Sandoval D, Zaytseva OO, Brock K, Sabyasachi B, Nachmanson D, Irvine EB, Armingol E, Mih N, Zhang Y, Jeffris M, Bartels P, Nguyen T, Tam A, Gasman S, Ilan S, Shamie I, Diedrich JK, Wang X, van Woudenbergh E, Altman Meghan, Aylward A, Bao B, Castro A, Sorrentino J, Chiang A, Campbell M, Bartsch Y, Aguilar-Calvo P, Sigurdson C, Alter G, Lauc G, Yates III JR, Marks D, Lisacek F, Lewis NE -
Advancing Antibody Engineering through Synthetic Evolution and Machine Learning
J ImmunolIrvine EB, Reddy ST -
Airway T Cells are a Correlate of i.v. Bacille Calmette-Guerin-Mediated Protection Against Tuberculosis in Rhesus Macaques
Cell Host MicrobeDarrah PA, Zeppa JJ, Wang C, Irvine EB, Bucsan AN, Rodgers MA, Pokkali S, Hackney JA, Kamath M, White AG, Borish HJ, Frye LJ, Tomko J, Kracinovsky K, Lin PL, Klein E, Scanga CA, Alter G, Fortune SM, Lauffenburger DA, Flynn JL, Seder RA, Maiello P, Roederer M
